Bors Study Guide Hematology

Front 1

The light-colored zone adjacent to the nucleus in a plasmacyte is the:

Back 1

golgi area

Front 2

The majority of the iron in an adult is found as a constituent of:

Back 2

2/3 of iron in body is bound to Hgb

Front 3

The main function of the hexose monophosphate shunt in the erythrocyte is to:

Back 3

provide reduced glutathione (to prevent oxidation of hemoglobin)

Front 4

Which hemoglobin chain is predominate in the fetus and continues to be even after birth?

Back 4

alpha polypeptide chain

Front 5

Which hemoglobin chain is present in low amounts the fetus but becomes one of the main hemoglobin chains after birth?

Back 5

beta polypeptide chain

Front 6

Which hemoglobin chain develops in high percentages during the fetal stage, but then drops after birth?

Back 6

gamma polypeptide chain

Front 7

Which hemoglobin chain is rare and can be present after birth?

Back 7

delta polypeptide chain

Front 8

Which hemoglobin chain is predominate during the beginning of the fetal stage but quickly drops?

Back 8

epsilon polypeptide chain

Front 9

In order for hemoglobin to combine reversibly with oxygen, the iron must be:

Back 9

in its functional form, ferrous

Front 10

What disease state is teardrop cells and abnormal platelets most characteristically seen?

Back 10

myeloid metaplasia (replacement of marrow with collagenous connective tissue fibers

Front 11

In the normal adult, the spleen acts as a site for:

Back 11

removal of imperfect and aging cells

Front 12

After removal of red blood cells from the circulation, hemoglobin is broken down into:

Back 12

iron, protoporphyrin, and globin

Front 13

Name: denatured hemoglobin inclusions that are readily removed by the spleen.

Back 13

Heinz bodies

Front 14

What hormone stimulates RNA synthesis of erythroid cells?

Back 14

erythropoietin

Front 15

What effect does spherocytes have on MCHC?

Back 15

increases MCHC

Front 16

What is a common characteristic of hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?

Back 16

red cell membrane defects

Front 17

What effect does microcytic, hypochromic anemia have on serum iron, TIBC, and storage iron?

Back 17

serum iron and iron storage decreases and TIBC increases

Front 18

What is the reulting effect on iron due to chronic blood loss?

Back 18

iron deficiency anemia

Front 19

Evidence indicates that the genetic defect in thalassemia usually results in:

Back 19

RNA deficiency resulting in decreased globin chain production

Front 20

Describe G-6-PD deficiency.

Back 20

an enzyme deficiency associated with a moderate to sever hemolytic anemia after the patient is exposed to certain drugs and characterized by red cell inclusions formed by denatured hemoglobon.

Front 21

Peripheral blood smears from patients with untreated pernicious anemia are characterized by:

Back 21

pancytopenia and macrocytosis

Front 22

The characteristic morphological feature in folic acid deficiency is:

Back 22

macrocytosis

Front 23

Myelofibrosis, causing macrocytosis, is often accompanied by what?

Back 23

folic acid deficiency

Front 24

A characteristic morphologic feature in hemoglobin C disease is:

Back 24

target cells

Front 25

Thalassemias are characterized by a decrease rate of:

Back 25

decreased rate of globin synthesis

Front 26

True or False: Decreased osmotic fragility is associated with hereditary spherocytosis.

Back 26

false

Front 27

What type of polycythemia is a severely burned patient most likely to have?

Back 27

relative polycythemia associated with dehydration

Front 28

The characteristic morphologic feature in lead poisoning is:

Back 28

basophilic stippling

Front 29

What is the approximate mean value of a reticulocyte on specimens of cord blood from healthy, full-term newborn?

Back 29

5.0%

Front 30

A RBC about 5 micrometers in diameter that stains bright red and shows no central pallor is a:

Back 30

spherocyte

Front 31

What is the characteristic, morphological feature associated with accelerated heme sythesis?

Back 31

polychromatophilic, nucleated red blood cells and basophilic stippling

Front 32

The characteristic peripheral blood morphologic feature in multiple myeloma is:

Back 32

rouleaux formation

Front 33

In polychtemia vera, the hemoglobin, hematocrit, red blood cell count and red cell mass are:

Back 33

elevated

Front 34

The M:E ratio in polycythemia vera is usually:

Back 34

normal, increase in both myeloid and erythroid precusors

Front 35

A common source of interference in the cyanmethemoglobin method is:

Back 35

very high WBC count

Front 36

The most appropriate screening test for detecting hemoglobin F is:

Back 36

Kleihauer-Betke

Front 37

The most appropriate screening test for hemoglobin S is:

Back 37

dithionite solubility

Front 38

What is the formula and units for MCH?

Back 38

(Hgb x 10)/RBC
pg

Front 39

What is the formula and units for MCHC?

Back 39

(Hgb x 100)/Hct
percent

Front 40

What is the formula and units for MCV?

Back 40

(Hct x 10)/RBC
fL

Front 41

What stain is used to identify siderotic granules?

Back 41

Prussian blue

Front 42

What and why is used to stain reticulocytes?

Back 42

new methylene blue, stains remaing RNA in the cell

Front 43

What stain is used to demonstrate iron, ferritin, and hemosiderin?

Back 43

Prussian blue

Front 44

What stain can be used to differentiate siderotic granules from basophilic stippling?

Back 44

Prussian blue

Front 45

True or False. Histiocytes contain hemosiderin.

Back 45

true

Front 46

Normal platelets have a circulating life-span of appoximately:

Back 46

9.5 days

Front 47

What drug affects platelet activity?

Back 47

aspirin

Front 48

In polycythemia vera, the platelet count is:

Back 48

elevated

Front 49

600e3/microleter of platelet count indicates what level of platelets?

Back 49

thrombocytosis

Front 50

Mucous membrane hemorrhages is characteristic of what?

Back 50

platelet disorders

Front 51

Considering platelets, what is characteristic of Bernard-Soulier syndrome?

Back 51

giant platelets

Front 52

A bleeding time is used to evaluate the activity of:

Back 52

platelets

Front 53

Platelet aggregation is dependent in vitro on the presence of:

Back 53

calcium ions