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31 Cards in this Set
- Front
- Back
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muscle specific actin
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myofibroblasts
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vimentin
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non-specific imminohistochemical stain mensenchymal components
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factor 13a
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dermal dendritic cells
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CD34
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dermal dendritic cells
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KP-1
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histiocytes
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HAM 56
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hisiocytes
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MAC 387
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histiocytes
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alpha-1 antichymotrypsin
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histiocytes
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skin tags assoc with birt-Hogg-Dube and Cowden S2 conventional skin tag
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no histo different
hamartomatous in origin skin tags in Birt-Hogg-Dube fibrofolliculomas, trichodiscomas, and perifollciular fibromas Cowden sclerotic fibromas not true skin tags |
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lipofibroma or fibroma molle
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larger skin tags with core of adipocytes
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pearly penile papules
incidence? |
30% of young postpubertal adults
mc in uncircumcised men |
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multiple facial angiofibromas
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ts 75% ptatients with TS
bilaterally on cheeks, nasolabial folds, chin, nose early to mid childhood more common than periungual angiofibromas |
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periungual fibromas
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angiofibromas
ts 40% by adulthood less common in TS than facial angiofibromas |
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angiofibroma histo
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dermal proliferation of biroblasts in a collagenous stroma
increas thin-walled dilated blood vessels collagen bundles perpiendularlly to epidermsi concentric around hair follicles and blood vessels decrease elastic fibers fibroblats can be stellate and multinuclated factor 13a pos, S-100 neg |
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2nd mc fibrohistiocytic tumor skin
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DF
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multiple eruptive DFs
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autoimmune disorders lupus
atopic dermatitis immunosuppression HIV |
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DF collagen polarized light?
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refractile to polarized light
peripheral keloidal collagen |
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sclerosing heamngioma
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DF hemorrhage
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DF into SQ
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radial pattern
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DF vs DFSP
location? stains? |
DF: extremities, factor 13a
DFSP: trunk, CD34 |
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DF stains
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Factor 13 a
vimentin muscle specific actin histocytic markers KP-1 and HAM 56 |
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DF with atypical cells
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middle-aged adults
larger > 1 cm large atypical mono and multinucleated cells with large pleomorphic and hyperchromatic nuclei and prominent nucleoli abundant vacuolated cytoplasm with hemosiderin deposits rare mitotic figures |
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Histo variants of DF
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1. with atypical cells
2. atrophic 3. deep DF extending into SQ 4. palisading 5. aneurysmal (agniomatoid, hemosiderotic sclerosing hemangiom) 6. with osteoclst-like cells 7. clear cell 8. xanthomatous 9. with granular cells |
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Pseudosarcomatous DF
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DF with atypical cells
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Atypical pseudosarcomatous cutaneous histiocytoma
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DF with atypical cells
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Fibrous histocytoma
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DF
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Deep DF
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trunk and proximal etremities of young to middle-aged patients
larger 1-2 cm 2 patterns into SQ 1. vertical or radial along the septae wedge-shaped 70% 2. base well circumsribed smooth depp margin 30% |
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acral fibrokeratoma
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acquired digital fibrokeratoma
collarette of elevated scale mc fingers middle aged trauma? |
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superficial acral fibromyxoma
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rare mensencymal
digits middle aged male 14 to 72 yrs ungual region deformity of underlying bone less common finger or palm no malignant dermis or sq not encapsulated stellate shaped cells storiform or fasccular pattern increase bv and mast cells CD34 pos with focal epithelial membrane antigen |
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sclerotic fibroma of the skin
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Cowden solitary or multiple, skin and/or mm, pearly papules or nodules, adulthood, M=F
sporadic solitary form no specific location |
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sclerotic fibromas
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well-circcumscribed dome shaped dermal hypocellular nodules
slceortic thick collagen CD34 pos variable collagen 4, prolcollagen, alaminin |
