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165 Cards in this Set
- Front
- Back
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Onychomadesis with pseudopyogenic granuloma of the proximal nail fold is a sign of what condition?
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Mild and transitory peripheral nerve injury
Seen in pts w/ phalanx, metacarpal or wrist bone fractures during or after cast immobilization |
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Yellos Nail Syndrome
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nephrotic syndrome, thryoiditis, tb, Raynaud's
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Schamroth Sign
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obliteration of the normal diamond-shpaed space at the proximal end of the nail when the distal phalanges are opposed
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zinc deficiency nails
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diffuse leukonychia
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Bywater's lesions
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painless reddish-brown infarcts nail fold
may darken and fall off leaving a tiny pit-like depression |
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Biwater's assoc ?
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RA vasculitis
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Biwater's assoc ?
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RA vasculitis
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acro-osteolysis
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vinyl chloride
Raynaud's Neuro disorders Haim-Munk Mandibuloacral Dysplasia: AR, LMNA/ZMPSTE24 idiopathic due to ischemia |
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mc nail tumor
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myxoid (mucous) cyst
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Red Lunulae
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AA
LE DM CHF Psoriasis CO poisoning LGV Reticulosarcoma 20 nail dystrophy |
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Terry's Nails
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CHF
POEMs DM |
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Dyskeratosis Congenita genes
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XLR DKC1
AD TERC (telomerase RNA component) |
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Zinsser-Engman-Cole Syndrome
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Dyskeratosis Congenita
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Hoyeraal-Hreidarsson
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DSK1 gene
allelic to dyskeratosis congenita posterior fossa malformations cerebellar hypoplasia pancytopenia short |
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Moeller or Hunter glossitis
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Atrophic glossitis assoc B12 def
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Scrotal tongue
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Pachyonychia congeita
Pemphigus vegetans Cowden Syndrome |
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macroglossia with crenations
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Beckwith-Wiedemann Syndrome
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granular cell tumor
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vimentin +
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Granular cell tumor type of cell?
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schwann cell
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White sponge nevus
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K4, K13
EM aggregated tonofilaments in ko |
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Hyper IgE basic deficiency
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deficient PMN chemotaxis
poor IFN gamma (no activator) in response to IL-12 Impaired IgE function elevated IgE by unopoosed IL-4 |
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Hyper IgE clinical findings
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eczema
cold abscesses respiratory coarse facies osteopenia/fractures + scoliosis Retained primary teeth, lack of secondary teeth IgE and IgD high perpiph eo |
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staph pneumatoceles
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Hyper IgE
can lead to aspergillomas |
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AR Hyper IgE
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TK2 tyrosine kinase 2
skin infections, PNA, high IgE severe viral chronic refractory molluscum and HSV NO FACE or BONE |
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mc death Hyper IgE
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lung infections
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Hyper IgE treatmetn
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Cimetidine
Interferon gamma improves no chemotaxis Gamma globulin decreases IgE |
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SCID
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XLR mc 50% gamma chain IL2 receptor gene
no T cells, NK cells NORMAL B CELLS AR ADA adenosine deaminase gene 20% no T, B, NK cells JAK3 in WBCs ZAP70 RAG1, RAG2, DCLRE1C |
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SCID
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seb derm, candidiasis, infection lungs, diarrhea
GVHD malabsorption PNA no thymus no tonsillar buds, lymphoid tissue death w/o BMT |
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Acquired C1 esterase inhibitor def
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monoclonal B cell
cyroglobulinemia Autoimmune |
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CH50 angioedema
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normal
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Danazol/Stanazol MOA
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stimulate functinoal C1 esterase inhibitor production
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Hereditary angioedema tx of acute flares
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FFP, epi, antihistamine, steroids
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refratory molluscum
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WAS or Hyper IgE AR
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Omen Syndrome
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Loss of eybrow and hair
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BLM
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chromo 15
DNA helicase important in DNA replication and repair |
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Bloom Syndrome triad? M or F?
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Telangiectasias erythema
Photo severe intrauterine and postnatal growth retardation |
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Bloom butterfly rash when
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2nd to 3rd week
cheilitis CALMs |
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mc eye finding Bloom's
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retinal drusen
colloid body-like spots other conjunctivitis, conjunctival telangiectasias, narrow anterior chamber, madarosis, iris pigment alteration and bilateral optic nerve hypoplasia |
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Blooms other assoc diseases
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DM 10%
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Bloom mc death? 2nd mc death
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malignancy
MC leukemia, lymphoma, adenocarcinoma 2nd mc chronic lung |
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Bloom's Disease defects?
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Dysfunctional helper T cells and abnl delayed hypersensitivy
defective lo maturation Low IgG,IgM,IgA |
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Bloom mc solid tumor
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Wilms tumor
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Rothmund-Thompson age onset skin
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3-6 mths
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Rothmund-Thompson malignancy
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premalignant acral verrucous keratoses
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Rothmund-Thompson clinical findings
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Alopecia
Dystrophic Nails Juvenile cataracts (age 3-7) Hypogonadism Dental Dysplasia Short with skeletal dysplasias Osteosarcoma, fibrosarcoma, SCC |
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Rothmund-Thompson immune system?
intelligence? |
normal
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mc malignancy Rothmund-Thompson
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cutaneous epithelioma (bc, scc, bowen's) 8%
then osteosarcoma |
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x-rays Rothmund-Thompson
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prior to age 3
long bones osteosarcoma 32% w 50% before age 15 |
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Cockayne Syndrome
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ERCC6 > ERCC8
mutated DNA repair (NER) XPB (ERCC3) and XPD (ERCC2) XPG(ERCC5) |
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Cockayne patients sensitive to light bt do not get pigment abnormalities or skin cancers
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XPG (ERCC5)
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Mueller's Muscle
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beneath levator muscle of upper eyelid
BTX |
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Adie's pupil
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mydriasis, loss of DTRs, diaphoresis
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polymethylmethacrylate (PMMA)
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microspheres in denatured bovine collagen and lidocaine
need hypersensitivity test |
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HA
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D-glucuronic acid
N-acetyl-D-glucosamine B1-3 and B1-4 onds negative charged |
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Poly-L-lactic acid
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sculptra
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Poly-L-lactic acid suspended
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sodium carboxymethylcellulose gel
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Restylane contraindicated?
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HA
contraindicated pt's severe allergies or anaphylaxis |
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Klippel-Trenaunay Syndrome mutations
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sporadic
angiogenic factor VG5Q IGF2 receptor |
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Klippel-Trenaunay vs Parkes-Weber D-dimer
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KTS slow = increased D-dimer
PW fast = nl D dimer |
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Cobb Syndrome
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stage 1 AVM skin
overlies intramedullary spinal cord AVM |
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Proteus rare tumors
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bilateral ovarian cystadenomas
Partoic monomorphic adenoma |
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Bannayan-Riley-Ruvalcaba Syndrome clinical
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AVM
big head joint laxity lipomas, angiomas |
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p57
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KIP2
cyclin-dependent kinase inhibitor |
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OBIULARIS ORIS INNERVATION
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BUCCAL
MARGINAL MANDIBULAR |
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BUCCINATOR INNERVATION
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BUCCAL
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LEVATOR LABII SUPERIORIS
ALEQUE NASI LEVATOR LABII SUPERIORIS ZYGMOATICUS MAJOR AND MINOR INNERVATION |
ZYTOMATIC
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LEVATOR ANGULI ORIS
RISORIUS INNERVATION |
BUCCAL
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DAO
DEPRESOR LABII INFERIORIS PLATYSMA MENTALIS |
MARGINAL MANDICULAR BRANCH
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MEDICATIONS ASSOCIATED WITH PYOGENIC GRANULOMA
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ZIDOVUDIN
MTX RITUXIMAB |
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LYME DISEASE MC CARDIAC
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FIRST DEGREE HEART BLOCK
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MARANTIC ENDOCARDITIS
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LIBMAN SACKS ENDOCARDITIS
NON INFECTIOUS VALVULAR VEGETATIONS HYPERCOAG STATES AND APS ACUTE SLE |
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CD79A
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B CELLS
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MIB-1
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KI-67
PROLIFERATION |
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LMP-1
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EBV
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ROSACEA INCREASE
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LL37: INDUCES ANGIOGENESIS ON ENDOTHELIAL CELLS
IL-8 IN KO STRATUM CORNUM TRYPTIC ENZYME (SCTE) IN EPIDERMIS |
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TLR-1
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DIACYLATED LIPOPROTEINS
TRIACYLATED LIPOPROTEINS |
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TLR-2
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TRIACYLATED LIPOPORETINS
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TLR3
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DSRNA
TRIF, IRF-3 IFN |
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TLR4
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LIPOPOLYSACCHARIDE
MYD88,IRAK, TRAF6 TRIF, IRF-3 NFKB IFN |
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TLR5
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FLAGELLIN
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TLR6
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DIACYLATED LIPOPROTEIN
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TLR8
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SSRNA
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TLR9
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CPG DNA
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TLR INDUCE NFKB
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MYD88, IRAK, TRAF6
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TLR INDUCE IFN
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TRIF, IFK3
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TLRS THAT INDUCE IFN
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3 ONLY IFN
4 NFKB AND IFN |
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INDIAN HEDGEHOG MAFFUCCI SYNDROME
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PROMOTES PROLIFERATION
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OLLIER DISEASE
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MAFFUCCI W/O VENOUS MALFORMATIONS
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BRACHAIL CLEFT CYST
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LYMPHOID FOLLICLES
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ACRODERMATITIS CHRONICA ATROPHICANS MC LOCATION
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SUN EXPOSED EXTENSOR LE
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MILROY DISEASE GENE
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AD FLT4 GENE ENCODES VEGFR3
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MILROY DISEASE OTHER SX
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HYPOPORTEINEMIA DUE TO GI LOSS
PULMONARY EFFUSIONS |
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STREETER'S DYSPLASIA
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AMNIOTIC FLUID BANDS
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DRUG URTICARIA
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OMEPRAZOLE
BILATERAL SYMMETRICAL LOW GRADE FEVER EOS AND EDEMA |
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LIVEDOID VASCULOPATHY ASSOC
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CTD
COLON, PANCREAS, PROSTATE CANCER HEMATOLOGIC MM, B CELL |
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PCT TYPES
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1. ACQUIRED/SPORADIC:ONLY IN LIVER
2. INHERITED AD AND AR UROPOPRHYRINOGEN DECARBOXYLASE UROD: LIVER AND RBCS |
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PCT ASSOC
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B THAL
VIRAL INFECTIONS: CMV DIALYSIS PATIENTS SLE DM |
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SCARLET FEVER TONGUE
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WHITE TO RED
WHITE 1-4 RED 4-12 |
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RECURRENT TOXIN MEDIATED PERINEAL ERYTHEMA
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KIDS
2-3 DAYS AFTER PHARYNGITIS MACULAR ERYTHEMA, EDEMA, DESQUAMATION HANDS STRAWBERRY TONGUE NO F/C C2 KAWASAKI |
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CLINDAMYCIN AND TSS
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PBPS
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STREP TSS
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SMEZ (STREP MITOGENIC EXOTOXIN Z) MOST POTENT
INDUCES TNFALPHA AND IFN GAMMA STREP TSS |
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STREP TSS BACTEREMIA PROGNOSIS
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NO AFFECT PROGNOSIS
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MARGINAL B CELL LYMPHOMA
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FEMALES
BORRELIA BURGFORFERI CD79, CD19, CD20 |
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FOLLICULAR CELL LYMPHOMA
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MALES
KAPPA OR LAMBDA LIGHT CHAINS, NOT BOTH TRUNK, HEAD/NECK, SCALP |
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SCLEROTHERAPY HIGHEST RISK FOR ANYPHYLAXIS
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SODIUM MORRHUATE
DETERGENT |
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ETHANOLAMINE OLEATE
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DETERGENT
SCLERO ESOPHAGEAL VARICES ARF AND HEMOLYITIC REACTION |
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POLVIODIDE IODIDE
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CHEMICAL IRRITANT
SCLERO ANAPHYLAXIS NOT FDA APPROVAL |
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GYCERIN
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CHEMICAL IRRITANT
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FDA SCLEROTHERAPY US
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SODIUM TETRADECYL SULFATE
SODIUM MORRHUATE HYPERTONIC SALINE: ABORTIFACIENT NOT FOR VARICOSE VEINS GLYCERIN FDA FOR CEREBRAL EDEMA AND ACUTE ANGLE GLAUCOMA |
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CICATRICIAL PEMPHIGOID HLA
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DQW7
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CICATRICIAL PEMPHIGOID LAMININ 332 OR EPLIGRIN
MC MAL |
ADENOCA
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CICATRICIAL PEMPHIGOID TOC ORAL AND CUTANEOUS
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DAPSONE
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BRUNSTING-PERRY
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CICATRICIAL PEMPHIGOID WITHOUT MUCOSAL
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IP MC FINDING
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TEETH > ALOPECIA, CATARACTS, SEIZURES > NAILS
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HYPOHIDROTIC ECTODERMAL DYSPLASIA GENES
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MC XL: ECTODYSPLASIN
AD, AR: EDAR (RECEPTOR), EDARADD (PROTEIN THAT INTERACTS W RECEPTOR |
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HYPOHIDROTIC ECTODERMAL DYSPLASIA ASSOC WITH SKIN
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SEB HYPERPLASIA
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WEGNER'S % WITH CUTANEOUS
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40%
PAINFUL SC NODULES PAPULES, VESICLES PETECHIAE PALPABLE PURPURA PG LIKE LESIONS |
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BILOPED ZITELLI MODIFICATION
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EACH LOBE 45 FOR TOTAL 90 ARC
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SPOKE WHEEL
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BCC
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SCEDOSPORIUM
MC DISSEMINATED PHAEOHYPOMYCOSIS |
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PAECILOMYCES
CORNEAL ULCERS |
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PENICILLIUM MARNEFFEI
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DIMORPHIC
SEPTATION BUDDING YEAST HAND BAMBOO RAT RHIZOMYS SINENSIS EASY TO CULTURE CD4 <50 AMPHO B |
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SCYTALIDIUM DIMIDIATUM
MOLD |
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SAPHO TX
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NSAIDS
CS TNF BLOCKERS MTX |
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PAPA SYNDROME GEN
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PSTPIP1 OR CD2BP1
CD BINDING PROTEIN 1 HYPERPHOSPHOYLATION AND INCREASED INTERACTION WITH PYRIN INCREASE IL-1B |
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ZOON'S FOUND IN PLASMA CELL
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IGE AND IGE
POLYCLONAL |
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INTERDIGITAL TINEA PEDIS MC
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E FLOCCOSUM AND T MENTAG
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CRYPTO STAINS YEAST
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PAS, GMS
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CYRPTO TLR
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TLR 4
GLUCURONOXYLOMANNAN |
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MITF
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MICROPTHALMIA ASSOCIATED TRANSCRIPTION FACTOR
DEVELOPMENT AND FXN OF MELANOCYTES INNER EAR MELANOCYTES RETINAL PIGMENT EPITHELIAL CELLS |
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TRANSCRIPTION FACTORS STRUCTURE
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DNA BINDING AMINO TERMINAL END
PROTEIN INTERACTION HELIX LOOP HELIX HOMODIMER TRANS-ACTIVATING DOMAIN BIND TAF P300/CPB PROTEIN (A HISTONE THAT TRANSFERES ACETYL GROUPS TO EACH HISTONE IN THE NUCLEOSOME) DESTABALIZES THE NUCLEOSOME AND ALLOWS GENES TO BE EXPRESSED |
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TIETZ SYNDROME
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MITF BASIC MOTIF CANNOT BIND DNA
HEARING LOSS BIRTH FAIR SKIN LIGHT HAIR |
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SNAI2
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WAARDENBURG TYPE 2
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HOX
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TRANSCRIPTION FACTOR
AXIS FORMATION |
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POU
PIT-1, UNC-86, OCT-2 |
PITUITARY DEVELOPMENT
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LIM
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HEAD DEVELOPMENT
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PAX
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NEURAL
EYE DEVELOPEMENT |
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SRY-SOX
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BEND DNA
ECTODERM DIFFERENTIATION |
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WEDGE
FLAP NOSE GRAFTS PROPHYLACTIC ABS |
KEFLEX 2 GM
DICLOX 2 GM CLINDA 600 MG AZITHROMYCIN 500 MG CLARITHROMYCIN 500 |
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GROIN/LE
PROPHLACTIC ABS |
KEFLEX 2 GM
BACTRIM ONE TAB LEVAQUIN 500 CETRIAXONE CLINDA AND GENT |
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ORAL MUCOSA PROPHYLATIC ABS
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AMOXICILLIN 2 GM
CLINDA 600 MG AZITHRO/CLARITHRO 50O MG AMPHICILLIN 2 GM |
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VP TX
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ACUTE: GLUCOSE AND HEMATIN
NO PHLEBOTOMY |
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VP WAVELENGTH
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626
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PIC PENIS AND UMBILICUS
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CRUSTED SCABIES
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IVERMECTIN
NEUROTOXICITY |
P GLYCOPROTEIN ABNL
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PILAR CYST ORIGIN
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ORS
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FOLLICULAR EPITHELIUM ORIGIN
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EIC
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PEMPHIGUS DRUG
CAPTOPRIL AND PENICILLAMINE |
SULFHYDRYL GROUPS INTERACT WITH SULFHYDRYL GROUPS OF DSG1 AND DSG3
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CLOACOGENIC CARCINOMA
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ANAL LOCATION
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ADENOID CYSTIC CARCINOMA
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CRIBIFORM
TUBULAR ATYPIA PINK SPONGE WITH PALE BLUE INK |
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B1
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THIAMINE
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B5
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PANTOTHENIC ACID
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B7
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BIOTIN
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B9
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FLIC ACID
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FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
GENE |
ENDOCHONDRAL OSSIFICATION
ACVR1 GENE |
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ECHOVIRUS MC
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ECHOVIRUS 9
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ECHOVIRUS RESEMBLING ACUTE MENINGOCOCCEMIA
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ECHOVIRUS 9
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ECHOMVIRUS DERMATOMYOSITIS LIKE FATAL ERUPTION
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ECHOVIRUS 24
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ECHOVIRUS 71
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ENCEPHALITIS
NEURO PULM EDEMA ASCENDING PARALYSIS S2 POLIOMYELITIS |
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BOSTON EXANTHEM
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ECHOVIRUS 16
MORBILLIFORM AND VESICULAR FACE, CHEST, BACK SOFT PALATE, TONSILS |
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ERUPTIVE PSEUDOANGIOMATOSIS
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ECHOVIRUS 25, 32
CULEX PIPIENS PALLENS MOSQUITO BITES JPAN VIRAL INFECTION |
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PAIN ON LATERAL AND UPWARD MOVEMENT OF EYE
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RUBELLA
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RUBELLA OR MEASLES FASTER PROGRESSION OF RASH
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RUBELLA FASTER
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ALPHA VIRUS
|
MULTIPLE ERYTHEMATOUS PAPULES WITH HALO FEVER ARTHRALGIAS
RESOLVE WKS HISTO S2 LYMPHOMATOID PAULOSIS BUT CD30 NEG |
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CHIKUNGUNYA VIRUS
|
AEDES
JOINTS HIG FEVER RAYNAUDS, ERYTHROMELALGIA, ACRAL COLDNESS LATE HA RASH +/- PRURITCI MORBILLIFORM ISLANDS OF SPARING APHTOUS LIKE ULCERATIONS ACUT ILLNESS BULLOUS ERUPTION DENGUE MORE NEUTROPENIA AND THROMBOCYTOPENIA |
