Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
Central tolerance for our own cells is established where?
|
In the thymus. Negative selection process 'deletes' any T-cells that may react with 'self' HLA molecules
|
|
What happens to T-cell lymphocytes that are specific for 'self' antigens?
|
They are deleted or rendered non-reactive (anergy).
|
|
Peripheral Tolerance (mechanism 1) is keyed by...
|
...the presentation without B7-leads to T-cell anergy
|
|
Peripheral Tolerance (Mechanism 2)
|
B-cells encounter an enormous amount of self-antigen & induce apoptosis
|
|
Peripheral Tolerance (Mechanism 3)
|
Suppression of immune response by Ts-cells
|
|
Auto-immune Response
Factors involved/reasons: |
Failure of clonal ablation
Genetic predisposition Polyclonal B-cell activation Th/Ts cell imbalance Hormonal Factors Immunologic cross reactivity Aging Defect in idiotypic-suppression network Alteration of tolerance by infections and inflammation |