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41 Cards in this Set
- Front
- Back
Catalase + bugs
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Staph, Kleb, Aspergillus, Serratia
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IL4
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activates B cells
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IFNg
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activates Macs
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Macs release what to activate T cells
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IL1, IL6, TNFa
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Costimulator molecules
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T-CD28
B - B7 |
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Adhesion molecules
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LFA1, ICAM1, LFA3, CD2
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B cell T cell interactions - stimulation
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MHCII and TCR - activation
Costimulation - CD28/B7, IL2, IL4, IL5 Class switching CD40L/CD40 |
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IL1 - macs
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pyrogenic, stimulates IL2 secretion
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IL2 - Th1, NK, Tc
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stimulates B, T cell GF
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IL3 - Tc
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stimulates BM
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IL4 - Th2, mast cells
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Stim B cells, IgG and IgE
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IL5 - Th2
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B cell diff, Eosinophils, IgA
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IL6 -
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acute phase proteins, B cells
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IL7
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stimulates pres
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IL8 - macs
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chemotaxis and adhesion of neutrophikls
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IL10
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downregs CMI, inhibits cytokine release
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IL12
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NK cells, induces Th0 --> Th1, increases CD8 and delayed type hypersensitivity cells
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TNFa - cytotoxic Tc, macs
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increases MHCI expression, increases inflammation
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TNFb - cytotoxic T cells
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increases MHCI, increases inflammation
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IFNg - Th1 cells
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stims macs, NK
inh Th2 cells |
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CD14
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endotoxin receptor - marker for macs
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essential step in CMI
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Th1 activation via MHC class II molecule - must be specific
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how do CD8s kill?
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perforin - cell membrane puncture --> lysis
granzymes: damages cell cytokines: IFNg and TNFb --> induces cell to produce enzymes to lead to its own death (apoptosis) fas/fas ligand: induces apoptosis on targe cell (if has fas) |
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how do NK cells kill?
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just like CD8s
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NK markers
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CD16, CD56
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NK-ADCC (ab dependent cellular cytotoxicity)
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Fc receptors (CD16) on NK that recognize IgG
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TNFb
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depresses protein synthesis, causes production of ROS
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classic pathway
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activated by antigen-antibody complexes
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alternative pathway
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activated by pathogen surfaces
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alternative pathway is to
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extrinsic pathway of coagulation cascade (activated by damaged vessels)
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classic pathway is to ..
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intrinsic pathway of coagulation cascade (activated by collagen, prekalikren, hageman factor) -- inflammation?
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complement functions
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1. recruitment
2. opsonization 3. MAC attack 4. clearance of immune complexes |
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anaphylatoxins
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C3a, C5a, C4a
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immune clearance and opsoinzation
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C3b
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C5a
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chemotaxis
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chemoattractants for eosinophils
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histamine, C5a, ECF-A, leukotriene B4, Platelet activating factor
contains - histaminase, aryl sulfatase, MBP |
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C3 deficiency
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increased susceptibility to pyogenic infxns
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C5-C8 deficiency
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recurrent neisseria infxns
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C1 inhibitor deficiency
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hereditary angioedema
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C2 deficiency
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increased incidence of connective tissue disorders
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C1, C4, C2 deficiency
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leukocyte adhesion deficiency - opsonization not efficient
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