Boards Endocrine And Diabetes Pharm

Front 1

Diabetes Drugs

Back 1

Diabetes Drugs

Front 2

NOTE: their are 6 types insulin
Lispro (fast acting)
Aspart (fast acting)
Regular (short duration)
Glargine (long duration)
Detemir (long duration)

Back 2

NOTE: their are 6 types insulin
Lispro (fast acting)
Aspart (fast acting)
Regular (short duration)
Glargine (long duration)
Detemir (long duration)

Front 3

What is the tx approach for TI DM?

T2 DM?

Back 3

Low sugar diet, Insulin replacement


Dietary Mods, Exercise, Oral hypoglycemics and insulin replacement

Front 4

Major AE of Insulin?

2 Other AEs?

Back 4

Hypoglycemia

Lipodystrophy @ injectino site
Wt Gain

Front 5

Tolbutamide,
Chlorpropamide,
Glyburide,
Glimepiride,
& Glipizide
all belong to what class of Drugs for Diabetes?

Back 5

Sulfonylureas

Front 6

MOA of sulfonylureas?

1st Generations can cause what?

2nd Generation can cause what?

Back 6

Inhib K+ release from pancreatic beta cells -->
depolar of pancreatic beta cells -->
Ca influx into pancreatic beta cells -->
Insulin release

Disulfuram like RXN

Hypoglycemia

Front 7

What is a drug used for diabetes that is a biguanide?

Back 7

Metformin

Front 8

Major MOA of biguanides?

Metformin is 1st line drug tx in who?

Most significant AE of metformin?

Metformin is CI'ed in who?

Back 8

Inhib gluconeogenesis

T2DM

Lactic acidosis

Renal failure

Front 9

2 Diabetes drugs that are glitazones / TZD?

MOA of TZDs?

Back 9

Pioglitazone
Rosiglitazone

Bind PPAR-gamma -->
Inc insulin sensitivity in peripheral tissue

Front 10

Which 2 diabetes drugs have the following AEs:

Wt gain
Edema
Hepatotoxicity
Heart Failure

Back 10

Pioglitazone
Rosiglitazone

Front 11

2 Diabetes drugs that are alpha-glucosideas inhibs?

MOA of acarbose and miglitol?

AE?

Back 11

Acarbose
Miglitol

Inhib alpha-glucosidase @ intestinal brush border

GI probs

Front 12

1 Diabetes drug that is a mimetic?

MOA of pramlitide?

Back 12

Pramlitide

Dec glucagon

Front 13

1 GLP-1 analog for diabetes?

MOA of exenatide?

1 AE?

Back 13

Exenatide

Inc insulin
Dec glucagon

Pancreatitis

Front 14

Lactic acid is a rare but worrisome SE

Back 14

Metformin

Front 15

MC SE is hypoglycemia

Back 15

Sulfonylureas

Front 16

Often used in combo w/ other oral agents

Back 16

Metformin

Front 17

Also helps lower TGs and LDL

Back 17

Metfotmin

Front 18

Not safe in settings of hepatic dysfnctn or CHF

Back 18

TZDs and Metformin

Front 19

Should not be used in pts w/ elevated serum creatinine

Back 19

Metformin

Front 20

Should not be used in pts w/ liver cirrhosis, elevated serum creatinine, IBD?

Back 20

Acarbose and Miglitol

Front 21

Hepatic serum transaminase levels should be carefully monitored when using these drugs

Back 21

TZDs

Front 22

Not assoc w/ wt gain, often used in overwt diabetics

Back 22

Metformin

Front 23

Metab'd by liver; good choice in pts w/ renal dz

Back 23

TZDs

Front 24

Primary effects post-prandial hyperglycemia?

Back 24

alpha-glucosidase inhibs

Front 25

Inhibs ca influx into panreatic beta cells

Back 25

Sulfonylureas

Front 26

alpha glucosidase inhib @ intestinal brush border

Back 26

Acarbose
Miglitol

Front 27

Agonist of PPAR-gamma receptors -->
Improved target cell response to insulin

Back 27

TZDs

Front 28

Other Endocrine Drugs

Back 28

Other Endocrine Drugs

Front 29

These 2 Rx block peroxidase -->
no organification of iodide -->
no coupling of TH synthesis

Additional MOA of PTU

Back 29

PTU
Methiomazole

Blocks 5-deiodinase -->
Dec peripheral conversion of T4 --> T3

Front 30

CU of PTU and methimazole

Back 30

Hyperthyroidism

Front 31

What 2 drugs do these AE describe:

Skin rash;
Agranulocytosis;
Aplastic Anemia

Back 31

PTU &
Methimazole

Front 32

Match PTU or methimazole to the following:

Hepatotoxic
Teratogen

Back 32

Hepatotoxic: PTU
Teratogen: Methimazole

Front 33

2 Drugs for thyroxine replacement?

Back 33

Levothyroxine & Triiodothyronine

Front 34

2 AEs of Levothyroxine and Triiodothyronine?

Back 34

Hypothyroidism,
Myxedema

Front 35

The following AEs match what 2 drugs:
Tachy,
Heat intol,
Tremors,
Arrhythmias

Back 35

Thyroxine,
Levothyroxine

Front 36

Some Hypothalamus / Pituitary Drugs:

1) This drug is used for GH defic and Turner's syndrome?

2) This drug is used for acromegaly, carcinoid, gastrinoma and glucagonoma?

3) This Rx stims uterine contractions, labor, can be used for milk let-down and uterine hemorrhage?

4) This drug can be used for CENTRAL (pit) NOT nephrogenic DI?

Back 36

1) GH

2) SS (Octreotide)

3) Oxytocin

4) ADH (Desmopressin)

Front 37

This ADH antag can be used for SIADH?

Back 37

Demeclocycline

Front 38

Which drug can cause nephrogenic DI, photosensitivity and abnorms of teeth and bone!

Back 38

Demeclocycline

Front 39

Used for addison's dz, inflammation, immune suppression, asthma and allergic rxns?

Back 39

Glucocorticoids

Front 40

Glucocorticoids can have this effect on bone?

Back 40

Osteoporosis

Front 41

Apart from hyperglycemia, what else could insulin be used for?

Back 41

Life threatening HYPERKALEMIA