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28 Cards in this Set
- Front
- Back
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Kell |
*glycoprotein *chrom 7 *K<10%; k>99% *IgG *Dosage occ *causes HTR and HDFN *found only on RBC |
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Kell System Ag Pairs |
*K, k *Kpa, Kpb, Kpc *Jsa, Jsb |
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K mod |
*weak expression of Kell ag *result of a point mutation on the KEL gene *Presence of Kpa may weaken other Kell ag expressions when in the cis position such as k and JSb |
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XK gene |
*variant kell phenotype *found on X chromosome *codes for kx ag *lack of this ag causes RBC deformity |
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McLeod Phenotype |
*results in mutation of the XK locus affecting Kx ag *affects males *RBC lack Kx ag and Km, have weak expression of kell ag *individuals demonstrate chronic hemolytic anemia |
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X-linked Chronic Granulomatous Disease |
*may be an association btwn rare kell phenotypes *dx characterized by WBC unable to generate an enzyme important to kill ingested bacteria *not all males w/ mcleod phenotype have CGD, or do all pts w/ CGD have mcleod phenotype |
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Anti-K |
*very common *K1 ag iv very immunogenic *Isotype: IgG 1, 3 (crosses placenta) |
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Anti-Ku |
*found in immunized K0 persons *directed against a single determinant (reacts w/ all cells except the K0 phenotype) |
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Duffy |
*glycoprotein *chrom 1 *IgG *shows dosage *destroyed by enzymes *Causes HTR and mild HDFN |
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Fya freq |
W 65%; B10%
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Fyb freq |
W 80%; B 23% |
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Duffy glycoprotein |
aka the duffy ag receptor for chemokines (Red cell receptor for interleukin-8)
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Duffy ag |
*may serve as a receptor for plasmodium vivax *null phenotype (prevents expression of duffy glycoprotein)--advantage against malaria |
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kidd |
*glycoprotein *chrom 18 (HUT 11 urea transporter gene) *IgG *dosage *enhanced by enzymes *binds complement, causes HTR, mild HDFN |
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Jka freq |
W 77%; B 91% |
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Jkb freq |
W 73%; B 43% |
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Jk3 freq |
100% as long as Jka and/or Jkb present |
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kidd null phenotypes |
*found in pacific islanders *rbcs are resistant to 2 M urea *rare |
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Kidd systems ab |
*fixes complement *weak expression *exhibit dosage *Jka more freq than Jkb *very common in htr |
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S, s |
*glycophorin B *IgG *dosage except U *enzyme destroyed except U *implicated in HTR and HDFN *chrom 4 |
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S freq |
W 55%; B37% |
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s freq |
W 89% B 97% |
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u freq |
100% |
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LW |
*associated w/ D but not part of the Rh system *cord cells have strong expression *test D- cord cells to discriminate btwn Rh and LW |
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LWa freq |
>99% |
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LWab freq |
<1% |
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High Prevalence Ag |
*Lan, Ata, Jra, Emm, AnWj, Sda, PEL, Mam *>91% *all are inherited |
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HTLA |
*rule out other specificities *prove its an HTLA by titration *usually transfuse least incompatible blood |
