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47 Cards in this Set

  • Front
  • Back
The main function of blood is
Transport
The formula for calculation of blood volume is
Blood volume in liters = .08 x Weight in kilograms
John weighs 100 kgs. His blood volume is ?
BV = .08 x 100 = 8 liters
Blood is composed of what two kinds of tissue?
Formed elements and unformed elements
Formed elements include?
Cells and parts of cells (Red Blood Cells, White Blood Cells, and Platelets)
What is "unformed" elements in blood?
PLASMA - What's left in the blood after the RBC's WBC's and Platelets are removed. There are NO CELLS in plasma! (by definition)
How many different stem cells give rise to RBC's WBC's and Platelets
ONE RBC's, WBC's and Platelets all come from the same stem cell
Define hematocrit
The hematocrit is the percent of blood occupied by RBC's
Which is the main cell found in blood?
RBC's make up 99% of the formed elements
RBC is a bag of
Hemoglobin
What cellular organelles are found in a RBC?
No Nucleus, mitochondria, or endoplasmic reticulum- it's a bag of hemoglobin
Where are RBC's made?
In adults, RBC's are made in the bone marrow
How long is the life span of a RBC?
120 days
What stimulates the formation of RBC's?
Erythropoietin (EPO)
What makes Erythropoietin?
The kidney
What does the kidney measure to regulate EPO release?
The oxygen carrying capacity of the blood.
What happens to old RBC's?
The are destroyed in the spleen, and the contents recycled.
What is the structure of hemoglobin
Four protein chains, each with a HEME group. Each HEME group has an iron atom. The O2 binds to the iron atom.
What are the nutritional requirements for hemoglobin production?
Iron, Folic acid, and vitamin B12
A normal hematocrit is ?
around 45%, 30% or less is quite low
A normal hemoglobin concentration is?
Around 15%, 10% or less is quite low
A normal WBC count is
Between 5,000 and 10,000 cells/mm3
What controls WBC production?
Colony stimulating factor
What do we call a WBC count that includes measuring the different types of WBC's?
A differential count, or a "diff"
What are the three types of granulocyte WBC's?
neutrophils, eosinophils, and basophils
What does a neutrophil do?
Neutrophils are a first responder to infections!
What does an eosinophil do?
Eosinophils are parasite fighters, AND are involved with allergies.
What does a basophil do?
Basophils made heparin and histamine to provoke inflammation.
What are the two types of agranulocytes?
Lymphocytes and Monocytes
What do lymphocytes do?
There are TWO kinds. Both fight infections.
What does a B lymphocyte do?
It makes antibody.
What does a T lymphocyte do?
IT provides cell-mediated immunity. It KILLS cells.
What do monocytes do?
Monocytes become macrophages.
What do we call the process white blood cells use to get out of the capillaries?
Diapedesis
What is the word for the attraction of white blood cells to the site where they are needed?
Chemotaxis
What do platelets do?
They are involved in hemostasis "stopping bleeding"
What is a normal platelet count?
130,000 to 300,000 platelets / mm3
How do platelets differ in structure from the other formed elements?
Platelets are PARTS of cells.
What cell gives rise to platelets?
Megakaryocytes.
Where are platelets made?
In the bone marrow.
Where is albumin made?
Liver
What does albumin do?
Among other things, albumin provides the colloid osmotic pressure.
What is the purpose of colloid osmotic pressure?
It helps to keep fluid from leaking out of blood vessels.
What is the purpose of lipoprotein?
To carry fats.
What is the purpose of gamma globulins?
Gamma globulins provide our immune response (antibodies))

The function of the RBC is ?

Carry oxygen

The function of the WBC is?

Defense against infections