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13 Cards in this Set
- Front
- Back
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how can you study CNS drug action |
behavoural tests methods used to identify site of action biochemical techniques brain imagine techniques electriophysiological techniques molecular biology techniquesgive so |
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give some examples of behavoural tests |
schizophrenia, epilepsy, anxiety, depression, addictionhat |
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what are the various levels of valitity of midels |
construct- model exactly mimics some aspect of the disease face- model produces symptomologies that resemble the disease predictive- drugs that work in disease work in model |
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what us lesioning studies |
damage parts of CN - cell bidy nuclei or nerve axon tracts surgical, electrical or chemical
then see what happens - in vivo/ vitro ligand binding - behavoural changes -brain imaging |
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wha is intracerebral injections |
use stereotaxic procedure - prefise location of site of injection use in lesioning procedures
linked to - behavoural, imagine, electrophysiological, autoradiographic techniques |
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biochemical techniques what is neurotransmitter turnover |
uses radiolabel monitoring measure increase / decrease jn precursor or metabolite molecules gives measure of neurotransmitter metabolism |
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biochemical techniques what is uptake and releae |
uses radio label monitoring uses fraction and centrifugation to determine cellular compartment of radio label |
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biochemical techniques explain radioligand binding studies |
used to determine the interaction between a ligand and its receptor gives no information about efficacy of ligand, only its binding affinity different types: saturation, kinetic, displacement |
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what does receptor autoradiography measure and use |
measure- receptor presence in vitro use- radiolabelled receptor ligand |
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what does positron emission tomography measure and use |
measures receptor presence in vivo use: radiolabelled receptor ligand |
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nsme some electrophyisological techniques |
extracellular (action potentials) - firing patterns and connectivity intracellular ( action potentials) - firing patterns and connectivity intracellular (synaptic potentials) -inhibitory neurotransmission excitatory neurotransmission |
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cloned and expressed receptor subtypes adv and disadv |
advantage- easily study receptors in isolation disadvantage - are isolated receptors the same as those in vivo? |
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explain using transgenic animals |
knock out- animals deficient in a selected gene knock in- animals containing an alien gene inducible- animals where genes can be switched on or off |
