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37 Cards in this Set
- Front
- Back
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NOTE: THESE ARE ALL BIOLOGICAL RESPONSE MODIFIERS
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:O)
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This blocks the ATP-binding site of c-abl making it effective treatment for Ph+ CML (9:22)
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Imatinib mesylate (Gleevac)
*mentioned in review |
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What else does imatinib mesylate inhibit?
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c-kit and PDGF associated tyrosine kinases
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Use and SE of imatinib mesylate
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GI stromal tumors and CML
Thrombocytopenia and Neutropenia |
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These inhibits EGF-receptor associated tyrosine kinases
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Erlotinib
Gefitinib *mentioned in review |
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Trastuzumab (Herceptin) Use and MOA
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Used for p185-her2 (=) breast cancer
Induces antibody-dependent cell mediated cytotoxicity |
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SE of Trastuzumab
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Cardiotoxicity
*esp. when combined w/anthracyclines |
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Cetuximab
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Chimeric monoclonal Ab directed against the EGF receptor
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Humanized monoclonal Ab directed against the VEGF receptor. What does it do?
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Bevacizumab
(-) angiogenesis *mentioned in review |
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Use of Bevacizumab? Risks?
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Metastatic colon cancer
Incerase risk of TE (thromboemolism) |
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Rituximab and MOA
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Recombinant chimeric (mouse/human) anti-CD20 monoclonal Ab
Promotes complement mediated lysis of malignant B cells in non Hodgkin's lymphoma *mentioned in review |
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One more time, what Rituximab used for?
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Non-Hodgkin's lymphoma
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Rituximab side effects
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Can result in HBV reactivation
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Mouse monoclonal anti-CD20 that can be linked to yttrium-90 or indium 111
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Ibritumomab tiuxetan(Zevalin)
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How does Zevalin work?
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Targets radioactivity to CD-20 expressing B cells
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Tositumomab can be linked to ?
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Mouse monoclonal anti-CD20 Ab that can be linked to I-131
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Gemtuzmab ozogamicin
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Recombinant monoclonal Ab directed against myeloid cell surface antigen 33
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What DNA cleaving Ab is conjugated w/gemtuzmab ozogamycin
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Calichaemicin
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Levamisole fxn
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Stimulates T cell activity
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IL-2 (Aldesleukin) fxn
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Activation of LAK (lymphokine-activated killer)cells
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Interferon alpha used for ...
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Multiple myeloma
Kaposi's sarcoma |
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Thalidomide used for
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Multiple myeloma
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All-trans-retinoic acid used for
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First line therapy for promyelocytic leukemia
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Arsenic trioxide use
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Second line therapy for actue promyelocytic leukemia
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Toxicities of arsenic trioxide
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Retinoic acid syndrome in acute promyelocytic leukemia
Cardiac arrythmias |
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Bexarotene
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Selective retinoid X receptor agonist
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Use of Bexarotene
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Cutaneous T cell lymphoma
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Denileukin difitox structure
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Recombinant chimeric protein containing the receptor binding portion of IL-2 fused to A and B subunits of Diptheria toxin
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Samarium SM 153 lexidronam structure
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Radionucleotide chelated to ethylenediamine tetramethylene
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Use of Samarium SM 153 lexidronam
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Preferentially distributes to bone- used for metstatic bone lesions
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Humanized anti-CD25 monoclonal Ab and its use?
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Alemtuzumab ( uh-lem-TOOZ-uh-mab)
Use for CLL |
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Bortezomib (bore TEH zo mib)and use
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Proteosome inhibitor
Multiple Myeloma |
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Celecoxib
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Inhibits COX-2
Prevention of colon cancer in pts. w/ familial adenomatous polyposis |
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Bisphosphonates (Etidronate, Pamidronate, Zoledronate) uses
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1. Hypercalcemia
2. Osteolytic bone lesions in MM 3. Metastatic breast cancer 4. Bone metastases from solid tumors 5. Prevention of bone loss in men taking leuprolide |
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Suppossed MOA of the bisphosphonates
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(-) of osteoclasts and induction of osteoclast apoptosis
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bacillus Calmette-Guerin use? Used with what?
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Bladder cancer
Epirubicin |
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Palifermin and use
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Recombinant version of human kertinocyte growth factor
Treats chemotherapy induced mucositis (good thing) |
