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20 Cards in this Set
- Front
- Back
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How do you treat D-amphetamine OD (3)?
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Nirtoprusside, alpha-blocker, sedative
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What two main uses are there for Modafinil?
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Hypersomnia
Cocaine dependence |
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What is methylphenidate preffered for?
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ADHD
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What is the main use of Sibutramine?
What neurotransmitter effects does it have? |
Obesity treatment
Enhances satiety and thermogenesis Inhibits 5-HT and NE uptake Little effect on DA (so not same "high") |
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What does Orlistat do?
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Inhibits dietary absorption of fat by up to 30%
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Where does orlistat act? What does it do?
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NOT a CNS drug
Acts in GI tract to inhibit pancreatic lipase |
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What can be used to stop cocaine-induced convulsions?
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I.V. Diazepam
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In treating narcolepsy, if cataplexy is also present, what drugs can be used (2)?
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Clomipramine
Fluoxetine |
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What is the mechanism of methylxanthines @ low doses?
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Competitive inhibition of adenosine A1 and A2 receptors
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What is the mechanism of methylxanthines @ high doses?
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Inhibit PDE --> Increased cAMP
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What are the two main uses of methylxanthines?
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Asthma
Treating primary apnea of prematurity |
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What is different about how premature babies respond to hypoxia?
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They REDUCE respiration
Methylxanthines are used to try induce respiration to normal |
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Which nicotinic receptors only respond @ high doses?
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Those @ neuromuscular junctions
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Which nicotinic receptors respond @ low doses?
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Those in ganglia, lungs, airway and the CNS
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In the brain, what does nicotinic activation of pre-synaptic receptors induce?
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Release of glutamate
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What does activation of nicotinic receptors on CELL BODIES induce?
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Increase in discharge rate of sympathetic neurons
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What does activation of nicotinic receptors on nerve endings promote?
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Increased Calcium entry
Increased NE release per AP |
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What is a risk @ high doses of nicotine?
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Depolarizing blockade and desensitization
Can cause CV collapse and muscle failure |
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How can toxic high doses of nicotine be treated?
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Gastric lavage w/ activated charcoal
NOTE: MUST AVOID ALKALINE SOLUTIONS (alkaline solutions enhance nicotine absorption) |
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What is the main therapy for nicotine addiction?
What drugs may help? |
Replacement therapy
Buproprion (Wellbutrin) |
