Block 3 Micro Exam -- Viral Replication (#2)

Front 1

Bacteriophage

Back 1

Viruses that infect bacteria

T4, lambda, phi29 are examples in lecture

In most phage, genome is dsDNA

Front 2

Host species for T4 and phi phages

Back 2

E. coli

Front 3

Host species for lambda29 phage

Back 3

Bacillus subtilis

Front 4

Steps of replication

Back 4

AIR EAR

Attachment
Injection (Entry)
Replication

Expression
Assembly
Release

Front 5

Typical role of EARLY proteins

Back 5

Involved in preparation for DNA replication

Front 6

Typical role of LATE proteins

Back 6

Involved in structural components

Front 7

Lysogen

Back 7

A cell carried an INTEGRATED phage genome

Front 8

Prophage

Back 8

The phage genome in a lysogen

Front 9

Cell surface receptor for Rhinovirus

Back 9

ICAM-1

Front 10

Cell surface receptor for HIV-1

Back 10

CD4
Chemokine (co-receptor) [CCR5 or CXCR4]

Front 11

Cell surface receptors for Rabies virus

Back 11

Acetylcholine receptor

Front 12

Cell surface receptor for influenza

Back 12

Sialic acid

Front 13

Virus fusion protein of influenza

Back 13

Hemagglutinin

Front 14

Virus fusion protein of retroviruses

Back 14

gp120

Front 15

Location of fusion for influenza viruses

Back 15

Endocytic vesicle

Front 16

Virus types that FUSE with endocytic vesicles

Back 16

Influenza virus (Orthomyxo)
Rhabdoviruses

Alphaviruses and ADENOviruses PENETRATE vesicles

Front 17

Fuseon

Back 17

Anti-HIV drug
Targets the membrane fusion process

Front 18

Location of poxvirus replication

Back 18

Cytoplasm
(unusual for DNA viruses)

Front 19

Location of influenza replication

Back 19

Nucleus
(unusual for RNA viruses)

Front 20

Viruses that can cause cancer

Back 20

KSHV
HPV
EBV
Hep B, C
HTLV-1

Front 21

DNA polymerase used by papillomaviruses

Back 21

HOST cell-encoded

Front 22

N-protein

Back 22

Coats RNA of MINUS strand viruses
Coating is there at ALL stages

Front 23

Viruses that have sub-genomic mRNAs

Back 23

Coronaviruses
Alphaviruses

Front 24

Viruses with segmented RNA

Back 24

BOAR

Bunyaviridae
Orthomyxoviruses
ARENAviruses
Reoviridae

Front 25

VHS

Back 25

HSV gene that causes degradation of host cell mRNAs

Only LATE HSV-1 mRNAs are spliced
(restriction against splicing is lifted)

Front 26

Viruses that have a pre-formed, nucleic acid-free capsid

Back 26

Herpesviruses
Reoviruses

Front 27

Location that HSV buds through

Back 27

Trans-Golgi membrane

Front 28

This virus family can spread by promoting local areas of fusion

Back 28

Herpesvirus

Virus passes through channel @ fusion site

Front 29

Cell surface receptors for HSV-1

Back 29

Heparan sulfate
Nectin 1

Front 30

Circular DNA viruses

Back 30

Papovaviridae
Hepadnaviridae

Herpesviridae DNA becomes circular during replication