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15 Cards in this Set
- Front
- Back
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Layers of epidermis
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Stratum Corneum
Stratum Granulosum Spinous Layer Basilar Layer Cells are known as keratinocytes |
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Dermatitis
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Widening of spaces between keratinocytes due to intercellular edema
Referred to as ECZEMA |
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Allergic Dermatitis
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Ex. Poison Ivy
Erythema and blistering develop Lesions are extremely pruritic Treatment is corticosteroids After sensitization, patient remains allergic for rest of life |
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Atopic Dermatitis
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Inherited predisposition to dermatitis
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Folliculitis
(Acne Vulgaris) |
Targets hair follicles
Disease of the follicular duct Follicular occlusion by keratin & sebum --> overgrowth of bacteria PMNs release enzymes and disrupt follicular wall --> inflammation |
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Leukocytoclastic Vasculitis
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Circulating ICs lodge in VENULAR walls
Complement components attract PMNs --> damage the vessels Clinical hallmark is palpable purpura (often on legs) Infiltration of vessel walls by PMNs Endothelial swelling, Thrombotic vessel occlusion Leukocytoclasis --> fragmentation of PMN nuclei |
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Erythema Multiforme
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Presents as an eruption of macules, papules, etc.
Steven-Johnson Syndrome --> mucous membrane involvement Toxic Epidermal Necrolysis --> exfoliation of skin Triggers: HERPES, infectious agents, drugs Histo -- Vacuolar degeneration, apoptotic bodies, perivascular lymphocytic infiltrate |
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Impetigo
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Caused by Stap Aureus or Strep Pyo
Spreads by direct contact HONEY-COLORED crusts Aggregates of PMNs at epidermal surface --> form SUBCORNEAL PUSTULE |
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Syphilis
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Primary lesion is chancre (painless)
Secondary syphilis --> condyloma lata and maculopapular eruption PALMS AND SOLES Gumma --> lesion of tertiary syphilis PLASMA CELLS are diagnostically useful Inflammation more granulomatous with advancing stages |
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Warts
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Induced by HPV
Verruca Vularis -- occur anywhere Verruca Plantaris -- soles of feet Verruca Plana -- flat wart, over the face Condyloma acuminatum -- anogenital region |
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Molluscum Contagiosum
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Flesh-colored, dome-shaped nodules with central keratotic cores
Common in children Causative member is POXVIRUS FAMILY Papules have invagination filled with molluscum bodies |
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Herpes Virus Infection
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Most commonly due to HSV 1 and 2, and Varicella-Zoster virus
Well known cause of fever blisters Herpes Zoster results from reactivation of latent virus in DRG Presents as eruption confined to a dermatome Nuclei are GUN-METAL GRAY |
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Diaper Dermatitis
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Candida
Pseudohyphae and yeast forms seen in stratum corneum |
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Tinea Vesicolor
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Caused by Malassezia Furfur (Pityrosporum)
White, scaly patches on the trunk Numerous yeast forms and short hyphae in stratum corneum |
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Scabies
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Caused by the human mite Sarcoptes Scabiei
Highly transmissable from person to person Itching is intense Commonly present on the fingerwebs, wrists, trunk, and genitalia |
