Bld 204 Exam 3 Clickers/quiz

Front 1

How many alleles of a proto-oncogene are
necessary for transformation of the cell

Back 1

1

Front 2

Genes that sense genomic damage are referred to

Back 2

Guardian

Front 3

The movement of a section of one chromosome to
another location on another chromosome is called

Back 3

Translocation

Front 4

Genetic alterations that are not the result of mutation,
but do result in a change in gene expression are

Back 4

epigenetics

Front 5

MicroRNAs code for proteins that
repress or increase gene expression.

Back 5

False

Front 6

One way cancer cell achieve self-sufficiency in
growth signals is

Back 6

over-repress growth factor receptors

Front 7

Mutations in ABL, specifically the translocation
from chromosome 9 to 22,
are seen in which condition

Back 7

CML

Front 8

Loss of heterozygosity means that only the
mutated allele is left.

Back 8

True

Front 9

The word that describes very poorly differentiated cells that do not interact properly with their
environment is

Back 9

Anaplasia

Front 10

Which is a funtion of human microbiome?

Back 10

Crowding out pathogens

Front 11

What is the hygiene hypothesis

Back 11

some human disease are related to being too clean

Front 12

Cancer cell growth factor expression is often

Back 12

autocrine

Front 13

reversible replacement of one adult cell type by another as an adaptation to stress is

Back 13

metaplasia

Front 14

what is the one thing that unifies all amyloid proteins that cause disease

Back 14

Beta plated sheet proteins

Front 15

HIV infection cases primary immunodeficiency

Back 15

FALSE (it should be secondary immunodeficiency, primary is something you're born with)

Front 16

Inversions occur between

Back 16

two chromosomes in a pair

Front 17

when tumor cells down regulate their expression of MHC I to be less visible to CTLs, they risk attach by which other cell type

Back 17

NK cells

Front 18

a growth factor receptor that is often mutated in cancer cells is

Back 18

EGFR

Front 19

all cancers seem to have mutations that effect
which check point in cell cycle

Back 19

G1-S

Front 20

bridge fusion breakage contributes to what very important
factor that contributes to cancer development

Back 20

genome instability

Front 21

What is nondisjunction

Back 21

improper separation of chromosome

Front 22

Translocation

Back 22

swapping genes among chromosomes

Front 23

chromosomal error in Klinefelter's Syndrome is

Back 23

XXY in a phenotypic male

Front 24

Phenotype means

Back 24

observable characteristics

Front 25

Screening tests for
prenatal genetic disorders
include:

Back 25

ultrasound

Front 26

new growth of tissue within the body that exhibits
abnormal division, maturation, and relationship
to its environment is referred to

Back 26

neoplasia

Front 27

what is a fundamental characteristic of all cancers

Back 27

abnormal differentiation

Front 28

besides the characteristics of cancerous growth,
what is one of the most important distinguishing factor when
deciding whether a growth is benign or malignant

Back 28

invasiveness

Front 29

heteroplasia is not a true neoplastic change
because the tissue changes

Back 29

cease when stimulation is removed

Front 30

Adenomas are

Back 30

benign and arising from glad or duct epithelium

Front 31

neoplastic differentiation and metaplasia are different
because metaplasia is

Back 31

reversible

Front 32

the word that describes veryl poorly differentiated cells
that do not interact properly with their environment
is

Back 32

anaplasia

Front 33

a growth factor receptor that is often
mutated in cancer cells

Back 33

EGF receptor

Front 34

All cancers seem to have mutations at which
check point in cell cycle

Back 34

G1-S

Front 35

RB is known as the governor because its regulation of

Back 35

the cell cycle

Front 36

reactivation of what enzyme allows cancer cells to
attain almost limitless replicative potential?

Back 36

Telomerase

Front 37

most often, cancers that spread via that bloodstream are

Back 37

sarcomas

Front 38

rapidly growing tumors must induce angiogenesis to survive.
signals from two specific growth factors help with this.
They are

Back 38

VEGF and FGF

Front 39

genes that sense genomic damage are

Back 39

guadians

Front 40

the increasing malignancy and resistance of cancerous growths
to treatment is referred to as

Back 40

tumor progression

Front 41

what specific type of cells are more likely to have balanced
translocation because their normal behavior

Back 41

lymphocytes

Front 42

a proto-oncogene that becomes an oncogene by
gene amplification in neuroblastomas is

Back 42

NMYC

Front 43

patients with nucleotides excision repair system
defects are more susceptible to what carcinogen

Back 43

UV light

Front 44

tumor cells may mask their antigens to avoid immune survelliance
what do they use to mask their surface antigens

Back 44

glycocalyx

Front 45

where is the worst body site for a tumor to arise in terms
of mechanical pressure

Back 45

brain

Front 46

an example of enzyme that is tested for mutations
in order to inform therapeutic decisions making is

Back 46

ALK kinase

Front 47

which of the tests below is a
diagnostic test for genetic disorder

Back 47

CVS

Front 48

what is genetic abnormalities that can be detected
by karyotype analysis

Back 48

inversion

Front 49

the genetic defect most often seen in Down's Syndrome is

Back 49

trisomy

Front 50

Familial Hypercholoesterolemia is
what type of genetic disorder

Back 50

autosomal dominant

Front 51

if frequency of mutant phenotype for male and female offspring
is equal but the parents my not have the
mutant phenotype, inheritance patter is

Back 51

autosomal recessive