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16 Cards in this Set
- Front
- Back
3 names for TCA cycle
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Krebs
Tri-carboxylic Acid (TCA) cycle Citric Acid Cycle |
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Amphibolic
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Both breaks down and builds up.
Contribues to catabolic and anabolic metabolism |
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Reactions of 8 Steps????
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1. condensation
2. Isomerisation 3. Dehydrogenase (Redox) 4. Dehydrogenase (Redox) 5. GTP generated - hydrolysis 6. Dehydrogenase (Redox) 7. Hydration 8. Dehydrogenase (redox) |
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Molecule that feeds into TCA cycle
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Acetyl CoA
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Order of molecules?
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A Clown In Kilimanjaro Sings Songs For Money Only
Acetyl CoA Citrate Isocitrate (Alpha) Ketoglutarate Succinyl CoA Succinate Fumarate Malate Oxaloacetate (OAA) |
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8 enzymes (In order from Acetyl CoA)
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1. Citrate synthase
2. Aconitase 3. Isocitrate Dehydrogenase 4. Alpha Ketoglutarate Dehydrogenase 5. Succinyl CoA Synthase 6. Succinate Dehydrogenase 7. Fumarase 8. Malate Dehydrogenase |
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For each molecule of NADH from TCA cycle ____ ATP molecules are produced
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3
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For each molecule of FADH2 from the TCA cycle _____ molecules of ATP are produced
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2
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For each turn of the cycle _____ ATP molecules are made
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12
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Can be used in pyruvate and glucose (from TCA cycle)
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Malate
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Can be used in Asparate, purines, pyrimidines, amino acids, and glucose (from TCA)
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OAA (Oxyloacetate)
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Can be used in fatty acids, cholesterol, and steroids (from TCA)
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Citrate
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Can be used in Glutamine, Glutamate, Purines, and other amino acids (From TCA)
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Alpha Ketoglutarate
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Can be used in Porphyrins (Heme and Chlorophyll) (From TCA)
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Succinyl CoA
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Anaplerotic
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A metabolic reaction that replenishes intermediates of TCA cycle (Fills up)
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3 main regulation points in TCA pathway (and most important?)
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1. citrate synthase is inhibited by citrate and ATP and activated by Acetyl CoA and Oxaloacetate.
2. Isocitrate dehydrogenase is inhibited by NADH and ATP and activated by ADP. 3. Alpha ketoglutarate dehydrogenase is inhibited by NADH and Succinyl CoA and activated by Calcium Ions. Rate of formation of Alpha Ketogluterate is important in overal cycle control |