Biochemistry Proteins Block Ii Spring 2010

Front 1

Removal of some amino acids from a protein:

Back 1

Proteolysis

Front 2

Insulin is synthesized as:

Back 2

Pre-ProInsulin

Front 3

This part of the single polypeptide chainof proinsulin is cleaved to yield active insulin and is sometimes used as a measure of insulin production in diabetics:

Back 3

C-Peptide

Front 4

This type of modification on Ser, Thr, or Tyrosine residues is a very common way of regulating the activity of proteins

Back 4

phosphorylation

Front 5

Name four types of covalent protein modifications:

Back 5

1. Proteolysis
2. Glycosylation
3. Phosporylation
4. Hydroxylation

Front 6

Directs proteins into the nucleus:

Back 6

Nuclear Targeting Signals

Front 7

Proteins targeted to the peroxisome have ______ sequence near their C-terminus:

Back 7

SKL

Front 8

This is a rare, fatal, genetic disease that results in empty peroxisomes because of failure to properly import proteins into peroxisomes:

Back 8

Zellweger Syndrome

Front 9

Proteins can be targeted to the __________ with signals at the N terminus rich in Ser, Thr, and other basic residues that make an amphipathic alpha helix:

Back 9

Mitochondria

Front 10

Proteins are imported into the mitochondria in an unfolded state associated with _______.

Back 10

Hsp70

Front 11

The protein signals that target the mitochondria are recognized by what two complexes of proteins?

Back 11

TIM and TOM

Front 12

This signal is located in the first 20-30 amino acids at the N-terminus and is found in secretory and plasma membrane bound proteins:

Back 12

Signal Peptides

Front 13

The polyribosomes synthsizing secretory and membrane bound proteins are directed where by the signal peptides?

Back 13

To the endoplasmic reticulum

Front 14

This RNA protein complex recognizes the signal peptide as it emerges from the ribosome as it is synthesized:

Back 14

Signal Recognition Particle

Front 15

The signal peptide is cleaved from the nascent protein by ________located in the ER lumen.

Back 15

Signal Peptidase