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9 Cards in this Set
- Front
- Back
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Is fatty acid synthesis the exact opposite of B-oxidation?
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No!
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Where does fatty acid synthesis occur?
Where does B-oxidation occur? |
The cytosol
In the mitochondrial matrix |
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Acetyl CoA transport
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From the mitochondrial matirx to the cyosol using malate/citrate/pyruvate shuttle
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1. Acetyl CoA-CE + malonyl-ACP-->B-ketoacyl
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B-ketoacyl synthase
-CO2 |
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2. B-ketoacyl-->B-hydroxyacyl
(ketone-->alcohol) |
NADP
B-ketoacyl reductase |
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3. B-hydroxyacyl-->enoyl reductase
(alkane/alcohol-->alkene) |
Dehydration
B-hydroxyacyl dehydratase |
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4. Enoyl reductase -->acyl
(alkene-->alkane) |
enoyl reductase
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Overall rxns for FA synthesis
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1. Condensation
2. Reduction 3. Dehydration 4. Reduction |
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FA synthesis regulation
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Insulin +
Leptin + glucagon - |
