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10 Cards in this Set
- Front
- Back
catalyzes the oxidation of Pyruvate to acetyl CoA there by providing a link b/t Glycolysis and TCA cycle. It is regulated by ATP demand.
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PDH Complex
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Brain is entirely dependent on the oxidation of ? to fulfill its ATP needs, and regulation of PDH complex is a life and death matter.
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Glucose
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Glycolysis takes place in the?
Pyruvate Decarboxylase and the Krebs cycle takes place within? |
Aqueous Cytoplasm
matrix of the mitochondrion |
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glucose is converted to pyruvate by glycolysis, then completely gets oxidized by CO2 following this pathway?
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PDH complex
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In cells/tissues w/ high energy charge, pyruvate is directed towards?
when charge is low? |
Gluconeogenesis
Pyruvate is preferentially oxidized to CO2 and H2O in the TCA cycle, w/generation of 15 equivalents of ATP/pyruvate. |
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central compund in metabolism in mitochondria.
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Acetyl CoA, product of the Pyruvate Dehydrogenase rxn.
High Energy thioester linkage makes it an excellent donor of the acetate moiety. |
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the bulk of ATP used by many cells to maintain homeostasis is produced by the?
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oxidation of pyruvate in the TCA cycle.
generates NADH and FADH2 |
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PDH Complex Enzymes? (3)
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Pyruvate Dehydrogenase
Dihydrolipoyltransacetylase dihydrolipoyldehydrogenase |
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PDH complex coenzy's?(5)
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TPP
Lipoic Acid Fad+ CoA NAD+ |
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Nutritional Deficiency of thiamine leads to the disease?
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Beriberi
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