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20 Cards in this Set
- Front
- Back
- 3rd side (hint)
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First step in TCA |
Acetyl CoA to Citrate Enz: citrate synthase |
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Pre step of TCA Substrate? Product? Enz? Process? |
Pyruvate to Acetyl CoA Enz: Pyruvate Dehydrogenase Process: Oxidative Decarboxylation |
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Where does TCA cycle occur |
In all cells with mitochondria (mitochondrial matrix) |
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TCA enzymes are found in ______ except _______ |
a. Mitochondrial matrix b. Succinate dehydrogenase (inner mitochondrial membrane) |
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TCA: enz with NADH byproducts |
1. Isocitrate Dehydrogenase 2. a-Ketoglutarate dehydrogenase complex 3. Malate Dehydrogenase |
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What is the component of a-ketoglutarate dehydrogenase complex |
(5) Thiamin diphosphate Lipoate NAD FAD CoA |
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Products of TCA |
a. 2 CO2 b. 1 GTP c. 3NADH d. 1 FADH2 |
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TCA rate limiting step |
Isocitrate Dehydrogenase |
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Step in TCA that requires Mn/Mg |
Decarboxylation of Oxalosuccinate to a-Ketoglutarate |
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TCA enz with 3 isoenzymes |
Isocitrate dehydrogenase 1 is only in mito= NAD required Other 2 in mito and cytosol= NADP required |
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TCA Substrate |
Acetyl CoA |
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TCA: enz with CO2 by products |
1. Isocitrate Dehydrogenase 2. a-Ketoglutarate dehydrogenase complex |
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TCA: enz with GTP as byproduct |
Succinate thiokinase |
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TCA: enzy with FADH2 as byproduct |
Succinate Dehydrogenase |
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Source of OAA |
Anaplerotic Reactions: Pyruvate Carboxylase (pre gluconeogenesis) |
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TCA: anaplerotic substrates aside from OAA |
(4) Glutamine Glutamate Aspartate Proprionyl CoA |
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ATP yield for TCA |
10 ATPs |
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Complete Oxidation of glucose in TCA |
30 or 32 ATPs |
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Inhibtor of Aconitase |
Fluoroacetate |
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Inhibitor/s of a-ketoglutarate |
(2) Arsenite Inc Ammonia |
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