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24 Cards in this Set

  • Front
  • Back

Functions of proteins

Enzyme catalysts, defense, transport, support, motion, regulation, and storage

Stereoisomers vs enamtiomers vs diastereomers

S: same backbone but different orientations


E: mirror images that can’t be superimposed


D: two/more differences between two stereoisomers

D or L: sugars and amino acids

Sugars: D


AA: L In humans


AA are D in bacteria

AA non polar and aliphatic

Val, Leu, Ile, Gly, Ala, Pro

AA branched chain

Val, Leu, and Ile


Also metabolized in the liver and the skeletal muscle

AA sulphur containing

Cys (polar) and Met (non polar)

AA aromatic

Phe (non polar), Tyr (polar), and Trp (non polar)


Also absorbs UV light At 280 nm

Phenylalanine facts you should know

Essential and forms tyrosine

Tyrosine facts

Precursor of melanin and is used for O-linked glycosylation


Catecholamines: dopamine, norepinephrine, and epinephrine act as neurotransmitters


Parkinson’s is a deficiency of dopamine


Synthesis of thryoxine

Tryptophan facts

Important for melatonin(circadian rhythm), serotonin(mood alterations), and source of niacin(deficiency causes hartnup disease)

AA with OH groups

Ser, Thr, and Tyr these are all polar


Used as targets for phosphorylation

AA acidic groups (polar)

Asp, Asn, Glu, Gln

Asparagine (Asn) is used for what

N-linked glycosylation

Chinese restaurant syndrome

Caused by MSG and symptoms due to excitogenic effects on Glutamate. Will be flushed and tired

AA with basic groups (polar)

Arg, Lys, and His(sometimes)

Arginine will be seen where

In synthesis of NO (which cause vasodilation), release of urea

Histidine

Neutral at physiological pH but can be positive or neutral depending on environment


Important buffer in plamsa

Essential AA

PVT TIM HALL


Phenylalanine, Valine, Tryptophan


Threonine, Isoleucine, Methionine


Histidine, Arginine, Leucine, lysine

Semi essential AA

Cys from Met


Tyr from Phe

Glucogenic, ketogenic, both?

Most are Gluco-


Keto- Leu and Lys


Both: Tyr, Ile, Phe, and Trp

pKa which have two or three values

AA with ionizable groups have 3 AA w/ Out ionizable groups have 2

Isoelectric focusing technique

Use pI to separate proteins

Maple syrup disease

Defect in breaking down of Val, Leu, and/or Ile


Sweet pee

AA with three pKa curves

His, Arg, Lys, Asp, Glu, Cys, and Tyr