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15 Cards in this Set
- Front
- Back
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Metabolic Role of Glucose |
energy source for brain, muscles and other organs RBC only use glucose Blood transports glucose Concentration in blood is regulated In absence of carbs, amino acids can be used to synthesize glucose |
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energy released by glucose |
-3000 kj/mol released by oxidation -only 5-6% is released during breakdown of glucose to 2 pyruvates -glucose catabolism produces intermediates for other metabolic pathways |
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Glycolysis |
10 steps net rxn glucose+2ADP+2P+2NAD -> 2 pyruvate+ 2 ATP+ 2NADH+ 2H+ +2H2O |
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Gycolysis Stage 1 |
Energy investment 2ATP, reactions 1-3 |
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Glycolysis Stage 2 |
Energy recovery, 4ATP, 2 NADH, reactions 4-10 |
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Step 1 Glycolysis |
Phophoryl group transfer, Phophoryl group transferred from ATP to Glucose to form glucose 6 phosphate, enzyme is hexokinase, 1 ATP is used |
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Step 2 Glycolysis |
g6p is converted to fructose 6 phosphate, enzyme, phosphoglucose isomerase, (ring opens and recloses) |
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Step 3 Glycolysis |
Phosphrylation of F6P, second ATP is used, F6P becomes Fructose 1,6, biphosphate, phosphofructokinase is enzyme, |
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Step 4 Glycolysis |
cleavage of Fructose 1,6 biphosphate into two trioses, enzyme is aldolase, produces GAP and DHAP (interconvertable), GAP continues along, |
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Step 5 Glycolysis |
Triose phosphate isomerization, triosephophate isomerase enzyme |
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Step 6 Glycolysis |
Oxidation and phosphorylation of GAP, exergonic reaction of aldehyde oxidation drives synthesis of 1,3 BPG, glyceradehyde phosphate dehydrogenase enzyme |
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Step 7 Glycolysis |
1,3 BPG dephosphorylation, 2 New ATP formed and 3GP, phosphoglycerate kinase enzymev |
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Step 8 Glycolysis |
3GP converted to 2GP, phosphate transferred within molecule to prepare reactant for next stage of glycolysis, phosphoglycerate mutase enzyme |
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Step 9 Glycolysis |
Dehydration of 2PG, makes PEP, enolase enzyme |
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Step 10 Glycolysis |
Pyruvate synthesis, catalyzed by pyruvate kinase 2 ATP created |
