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5 Cards in this Set
- Front
- Back
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Explain why a fatty acid, oleic acid (18 carbon, one cis double bond) has a lower melting point than stearic acid which has the sam number of carbons but is saturated?
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The presence of cis-double bond will make oleic acid bent, hence less tightly packed and more fluid. Therefore it stays as a liquid at lower temperature.
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Assume you have a protein that is 44kD that is composed of two equal length alpha helical domains. How many Angstroms long is each alpha helix?
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44kD/2 = 22KD 22kD/.11kD per amino acid = 2--*1.5 Angstroms per amino acid.
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Why is glycine conserved.
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It is saved for the positions where others can't fit. Thus it is conserved because of its versatility. A good example of the role of glycine is filling up the space in the protein collagen.
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Certain neurological diseases have been linked to protein infectious agents (prions). Explain why the study of protein three-dimensional structure and conformational change is essential to understand the underlying disease process.
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Prions are misfolded proteins that can convert properly misfolded alpha-helix rich forms of the proteins into the misfolded B-sheet rich form. This alternative protein conformation leads to protein aggregation and cell damage. This is the cause of several major neurological disorders in humans and animals, such as kuru, Creutzfeld Jacobs Disease, Mad-Cow disease, and scrapies
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What is the major protein in hairs? The shape of hair is determined in part by the pattern of S-S bonds. How can curls be induced?
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The major protein is alpha keratin. Disulfide bonds S-S in alpha keratin can be broken by the addition of reducing agents, making hairs more flexible. The disulfide bonds can then be reformed by oxidation.
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