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23 Cards in this Set
- Front
- Back
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What is the most common side effect of:
Cisplatin Cyclophosphamide Bleomycin? |
Cisplatin - Renal toxic
Cyclophosphamide - Hemorrhagic cystsitis Bleomycin - plumonary fibrosis |
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What enzyme is missing in phenylketonuria?
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phenylalaine hydroxylase
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What is the triad for pellegra?
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deficiency in niacin
dermatitis dementia diarrhea |
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Name each of the steps from phenylalaine to production of Epi
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Pheylalanine to Tyrosine
Tyrosine to Dopa Dopa to Dopamine Dopamine to NE NE to Epi*** |
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What 3 amino acids build up in maple syrup disease?
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defect in branch chain decarboxylase
hyperreflexia sweet odor urine 1. valine 2. isovaline 3. leucine |
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compare and contrast hexokinase and glucokinase and affinity for glucose
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Hexokinase
high affinity for glucose found in muscle cells Glucokinase low affinity for glucose found in the liver |
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What types of glycosidic bonds exist between the sugars of sucrose, glycogen, and cellulose?
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sucrose: alpha1-beta2
glycogen: alpha1,4 chains and alpha1,6 branches cellulose: beta 1-4 |
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What is the difference between fructosuria and fructose intolerance?
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fructose intolerance:
- deficient in fructokinase or aldolase B see severe hypoglycemia Fructosuria: deficient in fructoskinase fructose is harmless |
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Why does Von Gierke disease NOT involve skeletal muscle?
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GLucose 6-phosphate cannot cross membranes - remains trapped in liver cells, and inhibits glycogen breakdown. Some glycogen is cont. broken down by lysosmal alpha glucosidase which if deficient results in glycogen accumulation in all organs**
Type 1 glycogen storage diseases is deficient in glucose 6 phosphatase and see the liver and kidney enlarged...but not in skeletal muscle |
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How do you break down glycogen into glucose?
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glucose to glucose 1-P via: phosphorylase
glucose 1-P into glucose 6-P via: glucomutase glucose 6-P into glucose via glucose 6-phosphatase |
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what 2 mucopolysaccharides are defective in alpha L iduronidase?
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Hurler
Scheie |
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ok im am tired so no more questions just info slides
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mmmmm k
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fatty acids are either saturated, monosaturated, or polysaturated:
Palmitic acid - saturated linoleic acid - polyunsat linolenic acid - polyunsat oleic acid - monosaturated, only has 1 C=C double bond |
Enterohelatic circulation:
circulation biliary acids from the liver make bile in the small intestine. Bile acids aid in digestion of fats and move back to the liver |
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Triglycerides are made from:
3 FA + 1 glycerol |
Glycerophospholipids are made of:
1 glycerol + 2 FA + 1 phosphate head |
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Lectine: is a lipid**
it is a phosphatidyl choline |
Cardiolipid: is a lipid also
made of 2X phosphatic acid + glycerine |
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What sphingolipidosis is ass with blindness and a cherry red macula and more ass with Ashkenazi Jews????
Tay sacs man |
In Gaucher's disease:
Beta glucosidase is defective |
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Porphyrias are associated with photosensitivity
- causes oxygen free radicals which damages skin |
Lead will injure heme synthesis at delta-ALA to Porphobilinogen and Protoporphyin to heme
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Nl unfasted person nl energy for the brain is - glucose
for RBCs - glucose In a fasted state however..... brain - ketone bodies or glucose RBCs - use glucose still |
Beri-Beri
Have a thymine deficiency |
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Rubeola virus causes measles
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Coxsackie B virus causes myocarditis
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DOC for trichomonas is Metronidazole (both partners)
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DOC for Chlamydia is doxycycline
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DOC for Mycoplasma pneumonia is erythromycin or doxycycline
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DOC for Mycobacterium leprae is Dapsone and Rifampin
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aminoglycosides and tetracyclins work by attacking the 30S subunit
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chlorophenicol and macrolides work on the 50S subunit
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Plasmodia are in the sporozoite stage when they are injected into the human body
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Infectious mononucleosis is spread via EBV
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