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14 Cards in this Set
- Front
- Back
What are the four McGeers criteria for Neurotransmitters?
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Anatomical -have regional specificity
Chemical Physiological -should produce a physiologic response when administered Pharmacological |
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2 mechanisms neural excitement can occur?
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Depolarize (via Na ion channels)
Stimulate 2nd messenger systems |
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3 mechanisms that inhibition can occur?
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Hyperpolarizing
Blocking 2nd messenger systems Autoinhibition |
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What is autoinhibition?
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A neurotransmitter activates a receptor which leads to decreased release of that neurotransmitter
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What kind of neurotransmitters are GABA and Glutamate?
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CNS Gamma Aminobutyric acid is inhibitory and glutamate is excitatory
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How are Noradrenaline(NA or NE) and Dopamine(DA) related?
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NA is a derivative of DA both are result of Tyrosine modification.
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What are two other key CNS neurotransmitters?
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Serotonin (5HT produced from Tryptophan)
Acetylcholine |
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Are these neurotransmitters excitatory or inhibitory?
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Depends on the subtype of receptor and second messengers.
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What is a fundamental principle of biologic Psychiatry?
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Mental illness is due to disregulation of neurotransmission (too much or too little)
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How can there be a functional excess of neurotransmitter?
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-too much produced
-too much released -too many receptors -too sensitive receptors -too much 2nd messenger activity -faulty inactivation |
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What are some mechanisms of funcitonal deficiency of neurotransmitters?
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-not enough transmitter produced
-nout enough transmitter released -not enough receptors -insensitive receptors -ineffective 2nd messengers -excessive inactivation |
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What are some charcteristics of Parkinson's Disease?
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R- Rigidity
A -Akinesia/Bradykinesia T -Tremor (Pill rolling) S -Stooped shuffling gait |
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What is an underlying cause of Parkinson's?
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Deficiency of dopamingergic neurons
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What are four possible interventions (pharmacologic) for Parkinson's?
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-give dopamine precursor (L Dopa)
-block degradation -MOA inhibitor -give DA releasing agent (amitidine) -give DA agonist |