Basic Mechanisms Of Antibiotic Action

Front 1

mechanism of penicillin

Back 1

Binds PBPs and enzymes responsible forr peptidoglycan synthesis

Front 2

mechanism of cephalosporin

Back 2

Binds PBPs and enzymes responsible for peptidoglycan synthesis

Front 3

mechanism of cephamycin

Back 3

Binds PBPs and enzymes responsible for peptidoglycan synthesis

Front 4

mechanism of carbapenem

Back 4

Binds PBPs and enzymes responsible for peptidoglycan synthesis

Front 5

mechanism of monobactam

Back 5

binds PBPs and enzymes responsible for peptidoglycan synthesis

Front 6

mechanism and function of beta-lactamase inhibitors

Back 6

Binds beta-lactamases and prevents enzymatic inactivation of beta-lactam drugs such as penecillin (concurrent administration)

Front 7

mechanism of vancomycin

Back 7

inhibits cross-linkage of peptidoglycan layers by sterically interfering with D-alanine-D-alanine termini of peptidoglycan pentapeptide side chains

Front 8

mechanism of bacitracin

Back 8

inhibits bacterial cytoplasmic membrane and dephosphorylation of bactoprenol which moves peptidoglycan precursors out of cell

Front 9

mechanism of polymixin

Back 9

inhibits bacterial membranes by acting as a detergent and increasing permeability`

Front 10

mechanism of isoniazid

Back 10

synthesis of mycolic acid affected by disrupting elongation of fatty acids and hydroxy lipids; exact mechanism unknown

Front 11

mechanism of ethionamide

Back 11

disrupts cell walls by disrupting synthesis of mycolic acid.

Front 12

mechanism of cycloserine

Back 12

inhibits cross-linkage of peptidoglycan layers by inhibiting d-alanine-d-alanine synthetase and alanine racemase

Front 13

mechanism of aminoglycoside

Back 13

irreversibly binds 30S ribosomal subunit and causes abberant protein production and premature release of the ribosome

Front 14

mechanism of tetracycline

Back 14

reversibly binds 30S ribosomal subunits and prevents polypeptide elongation by blocking tRNA binding

Front 15

mechanism of oxazolidinone

Back 15

binds 50S ribosomal subunit and does not allow formation of 70S initiation complex thus preventing protein synthesis

Front 16

mechanism of macrolide

Back 16

reversibly bind 23S rRNA of the 50S ribosomal subunit which blocks polypeptide elongation.

Front 17

mechanism of clindamycin

Back 17

binds to the 50S ribosome and blocks protein elongation.

Front 18

mechanism of streptogramin

Back 18

binds to the 50S ribosome and blocks protein elongation.

Front 19

mechanism of chloramphenicol

Back 19

reversibly binds to the 50S ribosomal subunit thus blocking peptide elongation

Front 20

mechanism of quinolones

Back 20

binds DNA topoisomerases such as the alpha unit of DNA gyrase.

Front 21

mechanism of rifampin

Back 21

prevents transcription by binding DNA-dependent RNA polymerase

Front 22

mechanism of rifabutin

Back 22

prevents transcription by binding DNA-dependent RNA polymerase

Front 23

mechanism of metronidazole

Back 23

reduction of metronidazole's nitro group creates a cytotoxic compound that disrupts the host DNA.

Front 24

mechanism of metronidazole

Back 24

reduction of metronidazole's nitro group creates a cytotoxic compound that disrupts the host DNA.

Front 25

mechanism of sulfonamide

Back 25

competes with p-aminobenzoic acid to prevent synthesis of folic acid

Front 26

mechanism of dapsone

Back 26

inhibits dihydropteroate synthase, anti-folate

Front 27

mechanism of trimethoprim

Back 27

inhibits dihydrofolate reductates and distrupts folic acid synthesis

Front 28

mechanism of fosfomycin

Back 28

inhibits the first step in peptidoglycan synthesis where UDP-N-acetylglucosamine combines with PEP to form N-acetylmuramic acid