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21 Cards in this Set
- Front
- Back
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Most common type of Cutaneous T cell lymphoma? |
Mycosis Fungoides
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Pathogenesis of MF involves constitutive action of... cytokine profile of MF? |
JUNB and STAT3 TH2 |
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What labs do we follow to assess disease activity? |
Patch stage MF follow serum thymus and activation regulated chemokine (TARC/CCL17) to assess disease activity |
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Pathology of MF? |
superficial band like/lichenoid infiltrate of mainly lymphocytes enlarged atypical cells with cerebriform and sometimes hyperchromatic nuclei lymphocytes in epiD (epidermotropism) colonize the basal layer as single cells with vacuolated pillow (lump of coal) intraepidermal collections of lymphocytes (pautrier microabscess) bare underbelly sign |
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CTCL: Immunophenotype |
CD3+, CD4+, CD45RO+, CD8-, CD30- variable CD2, CD5, CD7, often loss of expression (if CD30+ happens to be expressed, it wil be MUM1+) |
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Large plaque parapsoriasis progresses to MF in what percent of cases? |
10% |
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hydrochlorothiazide and MF? |
may be a trigger... whack. |
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TMN staging for MF: T1: T2: T3: T4: N0: N1: N2: N3: N4: B0/1: B2: M0: M1: |
TMN staging for MF: T1: patches, ppaules and plaques <10% T2: patches, papules and plaques >10% T3: 1 or more tumors T4: erythema >80% BSA N0: no nodes N1: occasional to many lymphs in node N2: aggregates of atypical lymphs in node N3: complete effacement of LN N4: no confirmatory histology B0/1: <5% sezary cells B2: >1000/uL sezary cells M0: no visceral organs involved M1: visceral organs involved |
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Skin directed therapeutics for MF include: |
topical corticosteroids nitrogen mustard bexarotene radiation denileukin difitox |
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MOA of denileukin difitox? |
CD25 is the target of fusion toxin (IL2) fluid retention MC side effect |
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Side effects of bexarotene? |
hyperTG hypercholesterolemia central hypothyroidism leukopenia |
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MC location for follicular mucinosis? |
Head and Neck (esp eyebrow) |
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Course? |
Granulomatous slack skin Indolent clinical course: 1/3 associated with Hodgkin's disease, may evolve to/from MF |
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Triad of Sezary Syndrome? |
Aggressive and leukemic CTCL variant, only in adults: Erythroderma Lymphadenopathy Tcell clone in blood (>1,000 sezary cells/uL, CD4/CD8 >10/1 on flow cytometry) |
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Usually MF is CD30-, if it is CD30+, what does this indicate? |
CD30+ is associated with a more aggressive clinical course and poor survival |
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Chronic papulovesicular, papulopustular or hemorrhagic crusts with evolution to necrotic skin disease, mostly trunk and limbs --> usually asymptomatic and resolves over several weeks |
Lymphomatoid papulosis |
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Primary cutaneous anaplastic large cell lymphoma prognosis? |
10 year survival rate of 90% represents 12% of cutaneous t cell lymphomas |
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In a biopsy, the presence of what suggests the skin lesion is probably a metastasis from an underlying systemic lymphoma? |
ALK-1 |
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HOTS mneumonic for adult T cell lymphoma? |
HOTS hypercalcemia, osteolytic bone lesions, t cell leukemia, skin lesions |
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What type of virus is HTLV? A/w what lymphoma? |
retrovirus a/w adult t cell lymphoma (0.01-0.02%) |
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MCC cause of death in extranodal NK/T cell lymphoma, nasal type? |
lethal midline granuloma EBV associated lymphoma, common in Asia, Cental/South America |
