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9 Cards in this Set
- Front
- Back
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All lipodystrophies may be associated with what: |
insulin resistance, DM, dyslipidemia, acanthosis nigricans, hepatic steatosis, kidney disease, PCOS |
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Two types of lipodystrophy (in general) and their subsets
Basically just regurgitate that chart: |
I. Lipodystrophy A. Congenital 1. Generalized a. Berardinelli-Seip (females 3:1, fat loss everywhere but retroorbital and bone marrow, 20% risk of hepatic steatosis, AI hepatitis, dyslipidemia, diabetes, low leptin and adiponectin) 2. Partial a. Kobberling-Dunnigan (familial partial lipodystrophy, pancreatitis, diabetes, menstrual irregularity)
B. Acquired 1. Generalized- aka Lawrence syndrome, associated with JRA, SLE, type I diabetes, autoimmune hepatitis --> liver failure 2. Acquired Partial- aka Barraquer-Simms syndrome, looks like 80% of America, loss of fat of face and neck and arms, deposits on hips and LE, associated with membranoproliferative glomerulonephritis and low C3, a/w other autoimmune disorders 3. Acquired HIV- d/t protease inhibitors (all the navir drugs) 4. Acquired localized- 2/2 trauma (pressure semicircularis on thighs, annular on arms, centrifugalis on abdomen, injections, CTD |
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BUZZ:
aquired partial lipodystrophy (barraquer simms syndrome) |
a/w renal disease (membranoproliferative glomerulonephritis) and low C3 in 20% |
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BUZZ:
congenital generalized lipodystrophy |
20% risk of cirrhosis from hepatic steatosis or autoimmune hepatitis |
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Look out for what? |
Acquired partial lipodystrophy- loss of fat of face, neck, arms, trunk with excess fat on lower extremities
20% have membranoproliferative glomerulonephritis and C3 nephritic factor (low C3)
A/W other AID: DM, hypothyroid, RA, celiac, pernicious anemia, SLE, LCV |
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Characteristics of HIV lipodystrophy? |
double chin, buffalo hump, crixivan belly (fat deposits in neck, nape and trunk), related to >1yr of protease inhibitor therapy, switching therapy may reverse symptoms
peripheral lipoatrophy, central obesity, hyperlipidemia, IR |
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Which HIV drugs cause lipodystrophy? |
PI: saquinavir, ritonavir, indirnavi, navidinir
NNRTI: stavudine
Navir Stay with someone who has AIDs |
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Filler approved for HIV lipodystrophy? |
Radiesse and Sculptra |
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CD95 and lipoatrophy? |
Increased CD95 --> increased apoptosis of adipocytes (same MOA of endocrine cell apoptosis in type I dm and hashimoto thyroiditis) |
