Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
Clostridium tetani
|
Tetanospasmin (neurotoxin)
H subunit: binds neuronal gangliosides L subunit: blocks release of inhibitory neurotransmitters |
|
Clostridium botulinum
|
Botulinum toxin (neurotoxin)
Inhibits acetylcholine release at NMJ |
|
Vibrio cholerae
|
Choleragen (enterotoxin)
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl reabsorption) |
|
Escherichia coli (ETEC)
|
Heat labile toxin (enterotoxin)
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl resorption) Heat stable toxin (enterotoxin) Activates guanylate cyclase to produce GMP (inhibits NaCl resorption) |
|
Campylobacter jejuni
|
Enterotoxin
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl resorption) Cytotoxin Destroys mucosal cells |
|
Bacillus cereus
|
Heat labile toxin (enterotoxin)
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl resorption) |
|
Yersinia enterocolitica
|
Heat stable toxin (enterotoxin)
Activates guanylate cyclase to produce GMP (inhibits NaCl resorption) |
|
Shigella dysenteriae
|
Shiga toxin (enterotoxin)
A-5B: Inhibits protein synthesis of intestinal epithelial cells by inactivating 60s ribosomal subunit |
|
Escherichia coli (EHEC and EIEC)
|
Shiga-like toxin (enterotoxin)
A-5B: Inhibits protein synthesis of intestinal epithelial cells by inactivating 60s ribosomal subunit |
|
Staphylococcus aureus
|
Staphylococcal heat stable toxin (enterotoxin)
Toxic shock syndrome toxin 1 (TSST-1) (pyrogenic toxin) Superantigen: Activates the endogenous mediators of sepsis Tissue invasive toxins Lipases, Penicillinase, Staphylokinase, Leukocidin, Exfoliatin, complement binding factors |
|
Streptococcus pyogenes (Group A)
|
Streptococcus pyrogenic toxin
Superantigen: Activates the endogenous mediators of sepsis Tissue invasive toxins Hemolysins/Streptolysin: Lyses red blood cells Streptokinase: Activates plasminogen DNAse, NADase, Hyaluronidase |
|
Clostridium perfringens
|
Alpha toxin (tissue invasive toxin)
Lecithinase hydrolyses lecithin in cell membranes (cell death) |
|
Bacillus anthracis
|
Anthrax toxin
1. Protective antigen: binding 2. Edema factor: calmodulin-dependent adenylate cyclase increases cAMP 3. Lethal factor: zinc metalloprotease that inactivates protein kinase, causes TNF and IL1 release |
|
Corynebacterium diphtheriae
|
Diphtheria toxin
A/B: ADP ribosylation of elongation factor 2 leads to inhibition of protein synthesis |
|
Bordetella pertussis
|
Pertussis toxin
A/B: activates G proteins, adenylate cyclase increases cAMP Extracytoplasmic adenylate cyclase (Similar to edema factor) impairs chemotaxis and phagocytosis Filamentous hemagglutinin Binds to ciliated epithelial cells Tracheal cytotoxin Damages respiratory epithelial cells |
|
Clostridium difficile
|
A/B: causes fluid secretion and mucosal inflammation, leading to diarrhea
|
|
Pseudomonas aeruginosa
|
Pseudomonas exotoxin A
A/B: ADP ribosylation of elongation factor 2 leads to inhibition of protein synthesis |