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32 Cards in this Set
- Front
- Back
Cardioselective beta blockers (B1)and pneumonic
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AABBMEN
acebutolol atenolol betaxolol bispropolol esmolol metoprolol nebivolol |
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Nonselective beta blockers (B1 and B2) and pneumonic
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PPTN (precipitation) is bad
propanolol pindolol timolol nadolol |
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Nonselective antagonists(B1+B2+ alpha 1)
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Carvedilol
Labetolol |
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B-blockers with ISA activity
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I SAid Pin the Ace on the Label
ISA: pindolol acebutolol labetolol |
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B-blockers with MSA activity
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MJ SAid Pin the Ace on the Label Properly Becuz
MSA: pindolol acebutolol labetolol propanolol betaxolol |
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B-blockers used for migraine propylaxis
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Propanolol
Timolol |
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B-blockers that show a CHF survival benefit
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I Met two (Bis)Carvers, who saved me from CHF
Bispropolol Metopropolol Carvedilol |
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B2 antagonist effects
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Bronchoconstriction
Peripheral vasoconstriction slowing of glycogen metab lower blood glucose |
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B2 antagonists should not be used or used cautiously with which disease states?
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COPD (broncoconstriction)
Asthma Diabetes (glucose pathways) |
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B1 and B2 antagonist side effects
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Bronchoconstriction
Hypoglycemia Bradycardia CNS effects (depression) Cold extremities Arrhythmias (upregulation of R's with use) |
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Propanolol properties
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B1 and B2 antagonist
MSA Lipophilic (CNS effects) 1st line migraine propylaxis Anxiety Cyp2D6 metabolism Lots of 1st pass metabolism |
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First line migraine propylaxis drug
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Propanolol
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Nadolol properties
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Very long half life (14-24h)
hydrophilic Fewer CNS effects than Propanolol ! Prop is lipophilic no MSA or ISA |
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Timolol properties
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2nd line drug for migraine Px Opthalmic gel or oral
Open angle glaucoma Tx Can be absorbed systemically as an eye gel |
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Structural feature of B1 selective (cardioselective) antagonists
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para substitution increases B1 selectivity
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Dosing feature of cardioselective (B1) antagonists
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Selective for B1 at lower doses.
Less selective at high doses |
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Atenolol properties
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B1 selective
Hydrophilic (low CNS effects) Not metabolized Excreted unchanged HTN, Angina, Post MI |
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Atenolol indications
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HTN
Angina Post MI |
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Propanolol indications
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HTN
Anxiety Migraine prophylaxis |
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Betaxolol properties
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B1 specific
MSA HTN and Glaucoma No B2 so OK for asthma |
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Betaxolol indications and uses with disease states
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HTN
Glaucoma OK for asthma patients since no B2 antagonism |
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Esmolol properties
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IV administration
Very short (10 min) half life Superventricular Tachycardia TX Rapid acting Emergency use |
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Metoprolol properties
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CHF survival benefit
CYP2D6 metabolism |
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Nebivolol unique effect
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Elicits vasodialation of coronary blood vessels via activation of endothelial B3 R's
"nitrous oxide" pathways |
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B antagonists that provide a CHF survival benefit
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Metoprolol
Bispropolol Carvedilol |
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Nebivolol properties
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Most B1 selective antagonist
Elicits vasodialation of coronary blood vessels |
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Alpha 1 antagonist side effect
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orthostatic hypotension
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Labetalol properties
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B1+B2+alpha 1 antagonist
MSA ISA IV use in hypertensive emergencies |
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Carvedilol properties
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B1+B2+alpha 1 antagonist
Antioxidant effects CHF survivial benefit Lipophilic (CNS effects) |
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B blockers with greatest CNS effects
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Propanolol Metoprolol
Pindolol Carvedilol "Cant Make Proper Plans" on CNS drugs |
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B blocker for hypertensive emergencies
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Labetalol
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Metoprolol dosages
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Succinate (Toprol XL) has once daily dosing
Tartrate (Lopressor) has twice daily dose |