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35 Cards in this Set

  • Front
  • Back
After negative selection in the bone marrow, B cells migrate to where to wait for what?
peripheral lymphoid organs to wait for activation
Lack of CD19+ lymphocytes indicates a lack of
mature B cells
Btk is what enzyme essential for what step in B cell development?
Bruton's tyrosine kinase, inhibits second re-arrangement of heavy chain, thus stimulating proliferation and light chain re-arrangement
RAG-1 and RAG-2 result in what joining?
D-J and then V-DJ
Immature, Mature B cells have what on surface?
IgM, IgD
re-arrangement of H and L chains happen in what order?
DJ on both chrom - y
VDJ on 1st chrom -y/n
VDJ on 2nd chrom -y/n
kappa on 1st -y/n
kappa on 2nd - y/n
lambda on 1st - y/n
lambda on 2nd y!
An anergic B cell in the periphery with IgD is the result of?
self-reactivity to soluble self molecule in bone marrow
strong ligation of IgM to self antigen in bone marrow can trigger
arrest of development
light-chain re-arrangement
Positive selection for MHC class I and MHC class II happens where and results in what kind of T cells?
cortex of thymus
MHC class I CD8+
MHC class II CD4+
Negative selection of T cells happens where, is driven by what cells, and results in?
cortex/medulla junction of thymus
driven by dendrites and macrophages
thymocytes reacting strongly to self peptides are deleted
Thymocytes initially re-arrange which chain, then when that is over what is induced and what chain is re-arranged ?
beta chain
CD8/CD4 induction
then alpha chain
Re-arrangement of alpha loci can happen until?
the cell dies or receives a signal from a TCR
If there is no MHC(HLA) class II on the surface of cells, then there is no positive selection of what kind of T cells?
CD4+ T cells
T cells, after recognizing antigen presented by B cells, will express what and release what resulting in what?
cytokines (IL4, IL5, IL6, IL13)
B cell proliferation and plasma cell / memory cell creation
One example of T cell independent antigen?
Why are so many people 'allergic' to penicillin (and what is a name for this phenomenon?
because penicillin can conjugate with self proteins, then IgE antibodies are created against it!
Resting B cells versus plasma cells: main differences?
Resting B can isotype switch, has lots of surface Ig, has surface MHC class II, can grow and mutate.

Plasma secretes Ig, and has a little surface Ig
B cells enter lymph node how, become activated where, plasma cells gather where, plasma cells leave how to go where?
through venules, activate at T cell/medulla border, gather into a germinal center in primary follicle, leave through efferent lymph vessels to go to bone marrow and spleen
If a B cell mutates in the germinal center into presenting low affinity surface antigens it will?
undergo apotosis
If a B cell mutates in the germinal center into presenting high affinity surface antigens that cross links with helper T cells it will?
proliferate and mature into memory cells and plasma cells
Isotype switches to IgM IgG and IgA are driven by cytokines produced by?
T cells
Diffusion into extravascular sites and transport accross placenta are driven by Ig?
Ig for transport across epithelium?
CD64 is aka, has what structure, binds what Ig, induces what after ligation?
CD64 is FcgammaR1
has 72kDs alpha, gamma
binds to IgG1
respiratory burst in phagocytes and dendrites
CD16 is aka, has what structure, binds what Ig, induces what after ligation
CD16 is Fc gamma RIII
50 or 70 kDa alpha, gamma or epsilon
induction of NK cells
Fc epsilon RI has what structure, binds what Ig, induces what after ligation
alpha beta gamma
granule secretion
Free versus bound to pathogen Ig on macrophages?
free does not stimulate macrophage activation, bound to pathogen does
macrophages engulfs bacterium after what two events, then what do lysosomes do?
macrophage needs IgG and C3b on pathogen,
then the lysosomes fuse with the phagosome to degrade the bacterium
cytokines that regulate Ig isotopes inculde
IL4 IL5 IFNgamma TGFbeta
Plasma and memory cells are where
in lymph organ or go to marrow or spleen or site or..
T cell cytokines that induce B cell proliferation and maturation include
"armed" T cells express what three things?
high affinity IL-2 receptor
innate immune response causes dendritic cells to do what?
mature and migrate to secondary lymphoid site
IL13 is secreted primarily by what T cell and is associated with what physiological response?
Th2 cells in the allergic inflammation response
IL6 mediates which two responses?
Fever and acute phase from liver