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6 Cards in this Set
- Front
- Back
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ATP |
Adenosine triphosphate has electrical repulsion due to multiple electrical charges 3 -ve phosphate groups Unstable high energy molecule |
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ATP Synthesis: Overview |
ATP hydrolysis produces -50kJ of free energy Thus ATP synthesis requires energy This is from the electrostatic repulsion that needs to be overcome |
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ATP Synthase |
Fo: region is the membrane bound area of the protein F1: Comprised of the central stalks and the peripheral stalk, the central stalk acts as a rotor |
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ATP Synthase Main Features |
Proton transfer causes central stalk to rotata due to torque effect Torque effect: for every action there is an opposite and equal reaction (Newtons 3rd Law) Peripheral stalk remains static as a result conformational change occurs in alpha and beta subunits Conformation work brings ADP and phosphate close together poising them in an optimal configuration for reaction to occur |
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Going in Reverse: ATP Hydrolysis |
Conditions for reverse rotation -High ATP conc -Low proton conc in outer membrane Discovered by replacing F2 with a fluorescent protein |
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Oxygen and ATP Yield |
Oxygen provides main driving force for building proton gradient ATP yield without oxygen is substrate level phosphorylation (4 molecules) ATP yield with is oxidative phosphorylation (30 ATP from 1 glucose) |
