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24 Cards in this Set
- Front
- Back
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First line for long term treatment of persistant asthma
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inhaled corticosteroid
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MOA cromolyn
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inhibits mast cell degranulation
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MOA montelukast
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inhibits cysteinyl leukotriene receptors
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MOA zileuton
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inhibits 5-lipoxygenase and hence production of leukotrienes
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MOA omalizumab
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monoclonal antibody to IgE - prevents it from binding to its receptor on mast cells
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Side effects inhaled budesonide
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oral thrush, dysphonia,
reflex cough and bronchospasm |
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First drug to give for acute exacerbation of asthma
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short acting beta2 agonist
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side effect - liver toxicity
inhaled flunisolide cromolyn montelukast zileuton omalizumab salmeterol theophylline |
Zileuton
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side effect - anaphylaxis
inhaled flunisolide cromolyn montelukast zileuton omalizumab salmeterol theophylline |
omalizumab
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MOA salmeterol
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long acting beta2 agonist to cause bronchodilation
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MOA ipratropium bromide
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blocks muscarinic receptors to prevent/reverse ACh induced bronchoconstriction
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MOA theophylline
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PDE inhibitor to increase cAMP and cause bronchodilation
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side effects albuterol
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Palpitations
Sinus tachycardia Tremor Increased blood pressure |
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side effects theophylline
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GI problems, CNS stimulation, seizures, tachycardia, hypotension, cardiac arrhythmias
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1st line bronchodilator for long term treatment of persistant asthma
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long acting beta2 agonist - adjunct to antiinfammatory (ICS)
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ipratropium bromide
quick relief drug or long term control drug for asthma? |
quick relief drug - can add to SABA in ED
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theophylline
quick relief drug or long term control drug for asthma? |
long term control drug - adjuct to ICS/alternative to LABA
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montelukast
quick relief drug or long term control drug for asthma? |
long term control drug - alternative/adjuct to ICS
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comolyn
quick relief drug or long term control drug for asthma? |
long term control drug - alternative/adjuct to ICS
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When is the main use of prednisone in an asthmatic?
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Treat moderate to severe exacerbations - used only for a few days
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First line controller for COPD -
anti-inflammatory or bronchodilators? |
bronchodilators
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tiotropium bromide -
long term controller for asthma, COPD or both? |
COPD
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When do you use ICS in COPD?
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Add onto bronchodilators for chronic therapy of more severe COPD
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what anti-inflammatory drugs are used in COPD?
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corticosteroids
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