Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
44 Cards in this Set
- Front
- Back
- 3rd side (hint)
Shigella Flexneri & Salmonella Typhimurium |
Hijacks the rafts |
|
|
Plasma Membrane Blebs |
Detachment of plasma membrane and underlying actin filaments |
|
|
Malaria |
Treatment is chloroquine; Lysosomes
|
|
|
Dysfunction Lysosomes (General) |
Lysosomal Storage Disease; affects the hydrolytic enzyme or cofactor |
|
|
D/o of Spingolipid Degradation |
Gauchers Dse Tay Sachs Dse Sandhoff Dse Krabbe Dse Niemann-Pick Dse A, B |
|
|
Gauchers Dse |
Protein deficiency: Glucocerebrosidase Accumulation of Glucosyceramide |
|
|
Tay Sachs |
Protein: B- hexosaminidase, a-subunit GM2 Ganglioside |
|
|
Sandhoff Dse |
B- Hexosaminidase, B-subunit GM2 Ganglioside, Oligosaccharides |
|
|
Krabbe Dse |
Galactosylceramidase Gal-ceramide,gal-sphingosine |
|
|
Neiman-Pick Dse A, B |
Sphingomyelinase Sphigomyelin |
|
|
D/o of Glycoprotein Degradation |
Aspartylglycosaminuria a-mannosidosis |
Aspartylglycosaminidase N-linked oligosaccharides |
|
a-Mannosidosis |
a-mannosidosis a-mannosidosis |
|
|
D/o of Glycosaminoglycan Degradation |
Hurler syndrome (MPS I) hunter syndrome (MPS II) Maroteaux- Lamy Syndrome (MPS IV) |
|
|
D/o of Single Enzyme Deficiency |
Pompe Dse (glycogenosis II) Wolman Dse (familial Xanthomatosis) Canavan Dse (aspatoacylase Deficiency) |
|
|
D/o of Lysosomal Biogenesis |
I-cell Dse, mucolipidosis II |
|
|
D/o of Lysosomal Membrane |
Danon Dse Cystinosis |
|
|
Danon Dse |
LAMP2 presence of autophagic vacuoles |
|
|
Cystinosis |
Cystinosin Cystine |
|
|
1. Dse/s caused by malfunction of proteasome-mediated degradation
2. Overexpression of proteins causing acceleration of degradtion |
1. Angelman Syndrome Alzheimers Dse
2. Human Papillomavirus |
|
|
Inability of rER to export posttranslationally modified proteins to Golgi |
a1-antittrypsin Deficiency Result: EMPHYSEMA & Liver Damage
A1-antitrypsin inhibits Elastase (Proteasome) from breaking down Elastin. Elastin gives elasticity to lungs. One damaged, this will cause permanent elargement of airspaces. |
|
|
Mitochondrial Defects |
MERRF -MYOCLONIC EPILEPSY RED RAGGED FIBERS- muscle weakness, ataxia, seizures and cardiac and respi failure Mutation of mitochondrial dna gene encoding tRNA for Lysine. Affects ATP production |
|
|
Nonfunctional Peroxisomes; Faulty peroxisomal targeting signals or receptor |
Zellweger Syndrome |
|
|
Dse: Hijacking of actin polymerization machinery. Attacks host phagosome |
Listeriosis |
|
|
Affected in Inherited genetic dse |
Nucleus |
|
|
Werner syndrome (premature aging dse) |
Nucleolus |
|
|
Malfunctions of cell cycle leading to camcerogenesis |
Nucleolus |
|
|
Cystic fibrosis |
Plasma membrane |
|
|
Instestinal malabsorption syndrome |
Plasma membrane |
|
|
Lactose intolerance |
Plasma membrane |
|
|
Pseudoachondroplasia |
rER |
|
|
Calcium phosphate dihydrate crystal doposition dse |
rER |
|
|
Hepatic endoplasmic reticular storage dse |
sER |
|
|
I-cell dse |
Golgi |
|
|
Polycystic kidney dse |
Golgi |
|
|
Lewy bodies of PD |
Secretory vesicles |
|
|
Proinsulin diabetes |
Secretory vesicles |
|
|
MERFF MELAS KEARNS-SAYRE SYNDROME LEBER'S HEREDITARY OPTIC ATROPHY |
Mitochondria |
|
|
M-6-P receptor deficiency |
Endosomes |
|
|
LSD |
Lysosomes |
|
|
Zelwegger Syndrome |
Peroxisomes |
|
|
Alzheimers dse Diamond blackfan anemia |
Ribosomes |
|
|
Accumulation of misfolded proteins in cytoplasm: PD, ALZHEIMERS DSE, ANGELMAN SYNDROME, INCLUSION BODY MYOPATHIES |
Proteasomes |
|
|
Glycogen storage dse |
Glycogen |
|
|
GAUCHERS NEIMANN PICK LIVER CIRRHOSIS |
Lipid droplets |
|