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18 Cards in this Set
- Front
- Back
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Innate system |
first line of defense: external barrier
second line : cellular and chemical Fast, nonspecific, present at birth physical, chemical, cellular components |
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adaptive system |
third line : target specific pathogens slower, not present at birth, targets specific organisms develops and adapts post exposure antibodies, memory cells, plasma cells, B cells, T cells, |
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Immune system (PIC) |
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seroconverison |
antibody levels rise with time
results in false negatives in tests |
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Passive immunity |
placenta or colostrum (24 hours) sometimes human immunoglobulin is used |
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PAMPs |
pathogen associated molecular patterns recognized by PRR's (pathogen-recognition receptors) on macrophases, trigger innate response NOT antigen-antibody |
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Compliment system
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attach to PAMPS and cause cell lysis opsonize invaders to signal for phagocytosis can bind to antibody COMPLEMENT CASCADE RESULTS IN COMPLEMENT FIXATION (lysis or apoptosis) |
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Cytokines |
chemical signaling molecules interleukins, interferons, chemokines (chemtaxis) |
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Immunoglobulins (5) |
IgM -
IgG IgA IgE IgD MGAED Many girls are EDucated |
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IgM |
first exposure to antigen, temporary, largest |
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IgG |
Smallest and most common Produced and released from plasma cells in response to infection high levels indicative of chronic passive immunity to fetus |
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IgA
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mucosal surfaces oral or intranasal vaccines |
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IgE |
binds to ALLERGENS and triggers histamine from mast cells and basophils protects from parasitic helminth infections |
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IgD |
activates basophils and mast cells |
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Hypersensitivity reactions : Type 1
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- animal is sensitized via IgE - 2nd exposure is severe – anaphylaxis - atopy and food allergy as well |
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Hypersensitivity reactions : Type 2 |
- infection present, antibodies, complement - cross-reactive antibodies attack body’s own cells - example: IMHA |
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Hypersensitivity reactions : Type 3 |
- antibody-antigen (immune) complexes form - insoluble complexes deposit and initiate inflammation - example: lupus, vasculitis, glomerulonephritis |
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Hypersensitivity reactions : Type 4 |
caused by intracellular pathogens and accompanied by inflammation - cell-mediated reaction - example: Systemic Inflammatory Response Syndrome (SIRS |
