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43 Cards in this Set
- Front
- Back
What should the dose of drug that inhibits virus replication be?
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low
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what should dose of drug that is toxic be?
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high
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Which 2 drugs were found via blind screening?
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amantadine, acyclovir
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which was found by mech based screening? (1)
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Nevirapine
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What was determined by structure/computer based screening?
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influneza A NA
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Pleconaril-virus/step
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rhinovirus, attachment/entry, can't bind to ICAM, canyon
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amantadine
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influenza A uncaoting, prevents M2 binding, acidification fo endosome,
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fuzeon T-20-virus
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HIV-1 fusion to gp41, binds HR1, preventing interaction w/ HR2
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rimantadine (derivative of what)
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amantadine, influenza A prevents M2, endosome acidfication
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DNJ-2 viruses
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inhibits glycusodiase, HBV, HCV
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acyclovir (2)
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HSV, ZSV, nucleoside inhibitor,
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acyclovir (2)-imitaites what
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deoxyguanosine
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famcicylovir -derivative of what?
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acyclovir-HSV, ZSV, nucleotide inhibitor
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valacylcovir-derivatve of what?
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acyclovir-ZSV, HSV, nculeotide inhibitor
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AZT
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HIV-1 RT, nucleotsie imitator,
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AZT-imitates what
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thymidine
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2' C methylcytidine
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HCV, flvavirius , nucleoside inhibitor -
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NM283 -derivatve of what
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2'C methylcytidine, prodrug
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Stavudine-dericvative of ?
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thymidine, nucleoisde inhibitor
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Nevirapine
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HIV-1 RT, non nucleotide inhibitor
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rescriptor
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HIV-1 RT, non nucleotide inhibitor
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Sustiva
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HIV-1 RT, non nucleotide inhibitor
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Foscarnet (3)
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HSV DNA pol, non nucleotide inhibitor, HIV RT, Hep B pol
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MK 0158
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HIV integrase inhibitor, non nucleotide
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GS9137
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HIV integrase inibitor, non nucleotide
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Ritonavir
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HIV protease PRO/RT
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Squinivir
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HIV protease MA/CA
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Darunavir
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protease
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Indinvair
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protease
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Zanamivir
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neuraminase inhibitor (release), influenza A
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Ostelamivir
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release, influenza A neuraminase
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Zanamivir-powder or oral
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powder, bad for asthma/lung
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Ostelamivir-powder or oral
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oral , bad for stomach, headache, diarrhea
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Peramivir (5)
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influenza neuroaminase, HBV, HCV, polio, measles
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Peramivir -inhaled/oral
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oral
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Ribavirin-tons of stuff-resmebles what?
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adenosine, guanosine
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Ribavirin-tons of viruses-inhibits? what step
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release, IMPDH, inhibiting GMP, RdRp, virion production
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side effects Ribavrirn
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hemoltyic anemia
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viramidine
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derivative of ribavirin, not so much trapped ine rythrocytes, inhibits release
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which drug is phosphorylated by all cellular TK?
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valacyclocvir
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which drug has HSV/ZSV TK first then all cellular TK?
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acyclovir
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48 h before taken, how many days saved?
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1 day
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30 hours before taken, how many days saved?
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3 days
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