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6 Cards in this Set
- Front
- Back
ethambutol |
Inhibits transfer of mycolic acids into cell wall of tubercle bacillus |
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isoniazid |
Prodrug, which once activated, inhibits synthesis of mycolic acids (essential component bacterial cell wall) |
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pyrazinamide |
Mechanism unclear. Metabolite (pyrazinoic acid) may lower intrabacterial pH to level that could inactivate vital target enzyme (e.g. fatty acid synthase. |
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rifampicin |
inhibits DNA–dependent RNA polymerase activity in bacillus |
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nystatin |
Binds to sterols in cell membrane of susceptible species, resulting in increased membrane permeability and subsequent leakage of intracellular components. |
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aciclovir |
As triphosphate, competitively inhibits viral DNA polymerase and competes with natural deoxyguanosine triphosphate for incorporation into viral DNA, thus acting as chain terminator |