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18 Cards in this Set
- Front
- Back
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Ciprofloxacin
(class & MoA) |
fluoroquinolones
Gm-: inhibits DNA gyrase Gm+: inhibits topoisomerase IV |
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Levofloxacin
(class & MoA) |
fluoroquinolones
Gm-: inhibits DNA gyrase Gm+: inhibits topoisomerase IV |
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Gatifloxacin
(class & MoA) |
fluoroquinolones
Gm-: inhibits DNA gyrase Gm+: inhibits topoisomerase IV |
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Moxifloxacin
(class & MoA) |
fluoroquinolones
Gm-: inhibits DNA gyrase Gm+: inhibits topoisomerase IV |
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Ciprofloxacin
(main use) |
Pseudomonas
UTIs, prostatitis, STDs, gastroenteritis |
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Levofloxacin & Moxifloxacin
(main use) |
respiratory infections
(S.pneumo, CAP) |
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FQs absorption & adverse effects
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absorption inhibited by heavy metal ions
tendon ruptures & cartilage damage (also, GI, rash, CNS) |
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Rifampin
(MoA & main use) |
inhibits RNA poly (transcription)
Treats TB or N. meningitides |
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Rifabutin
(MoA & main use) |
inhibits RNA poly (transcription)
Treats TB or N. meningitides |
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Rifampin & Rifabutin effect on CYP3A4?
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inducers
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Sulfonamides MoA
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analog of PABA
inhibits folic acid synthesis by inhibiting dihydropteroate synthetase |
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What sulfonamide is shortest acting?
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Sulfisoxazole
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What is silver sulfadiazine used for?
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prevent colonization of burns
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What is the main use of sulfonamides?
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uncomplicated UTI, nocardiosis, trachoma, conjunctivitis, toxoplasmosis
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Sulfonamides adverse rxns
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skin (rash-->SJ), drug fever, blood dyscrasias, eosinophilia, crystalluria, hepatitis, kernicterus
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Trimethoprim MoA
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inhibits DHF reductase (prevents conversion of FH2-->FH4)
inhibits utilization of folate |
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Trimethoprim uses
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bronchitis, otitis media, Pneumocystis jiroveci
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Which 2 antibiotics show slowed absorption when heavy metals are present?
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Ciprofloxacin and Tetracycline
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