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15 Cards in this Set
- Front
- Back
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What is the order of drugs that you give for HTN?
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1. diet modification
2. diuretics 3. Ace inh/ARBs 4. CCBs, 5. beta-blockers |
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Diuretics:
drugs; major facts |
thiazides--> for chronic HTN, hypercalcemia, hypokalemia, hyperglycemia
loop--> for acute HTN, hypocalcemia, hypokalemia |
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Clonidine:
MOA, CU, AR |
MOA: block alpha 2 receptors and cause depletion of NE
CU: acutely in ER for HTN, used for narcotic and alcoholic withdrawal AR: severe rebound HTN (when withdrawn), xerostomia, impotence, edema |
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Methyldopa:
MOA, CU, AR |
MOA: false NT, reduces NE conc
CU: severe HTN AR: lots of impotence, sedation, POSITIVE COOMBS test, edema |
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Guanethidine and Guanedrel:
MOA, CU, AR |
MOA: displacement of NE from vesicle, works better orthostatic than supine
CU: severe HTN AR: diarrhea, orthostatic HTN, impotence, tolerance |
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Alpha 1 blockers:
drugs, MOA, CU, AR |
drugs: Prazosin, Terazosin, Doxazosin, Tamsulosin
MOA: block alpha 1 receptor; also inh cyclic nucleotide phosphodiesterase CU: chronic HTN AR: 1st dose syncope, headaches, no tachy |
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Reserpine:
MOA, CU, AR |
MOA: depletion of NE by blocking ATPase
CU: HTN AR: suicidal thoughts, depression, sedation, impotence |
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Beta blockers:
Drugs |
atenolol--> #1 for HTN, #1 for prevention of MI
propanolol--> CNS effects Labetlol--> #1 ER HTN |
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Hydralazine:
MOA, CU, AR |
MOA: increase N; works on arterial side
CU: HTN, decreases diastolic BP more AR: tox in slow acetylators, lupus like rxn |
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Minoxidil:
MOA, CU, AR |
MOA: inc NO, inc K perm and hyperpolarizes cell
CU: works on arterial side; severe HTN AR: hypertrichosis, pericarditis, reflex tachy |
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Diazoxide:
MOA, CU, AR |
MOA: increase NO, stim K channels and causes hyperpolarization
CU: works on arterial side, HTN-ive crises AR: hyperglycemia, tolerance, reflex tachy |
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Nitroprusside:
MOA, CU, AR |
MOA: increases NO, short duration
CU: arterial and venous side, HTN-ive crises AR: cyanide poisoning b/c of metab |
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Nitroglycerin:
MOA, CU, AR |
MOA: increase NO
CU: HTN-ive crises, angina or MI AR: headaches, hypotension |
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CCBs:
Drugs, MOA, CU, AR |
Verapamil and Diltiazem
Verapamil--> more with heart and Diltiazem--> more on periphery MOA: blocks voltage sens Ca channels CU: decrease TPR in arterioles, antiarrythmics (V/D); #1 drug of CCBs for HTN (Amlodipine) AR: cardiac arrests, arrhythmias |
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Ace inh/ARBs
Drugs, MOA, CU, AR |
Ace inh: Captopril, Lisinopril, Enalapril
ARBs: Losartan, Valsartan MOA: block ACE CU: #1 drug for HTN in Diabetics and people with kidney probs AR: hyperkalemia, teratogenic, fetal renal tox , cough (not in ARBs) |
