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5 Cards in this Set
- Front
- Back
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ε-aminocaproic acid
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Lysine analogue
Used to reverse tPA and other fibrinolytic overdose by blocking fibrinolysis Complications: thrombosis, GI side effects, myalgia |
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Tranexamic acid
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Synthetic analogue of lysine
Binds to plasminogen blocking conversion to plasmin. Also blocks plasmin protease activity Indications: bleeding from overdosage of thrombolytics, hemophilia |
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Aprotinin
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Serpin that inhibits Alteplase, Streptokinase, Urokinase, Kallikrein and Plasmin
highly antigenic: from bovine |
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Protamine Sulfate
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Binds and inactivates Heparin
Side Effects: Hypotension, bradycardia, dyspnea, flushing Cross-reactivity with NPH insulin allergies fish sperm |
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Vitamin K
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these factors need it: Factors II, VII, IX, X, protein S, protein C and protein Z
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