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18 Cards in this Set

  • Front
  • Back

How does warfarin work

Inhibition of Vit K reductase (Vit K antagonist)


Affects factors 2,7,9,10

How is warfarin monitored

INR aim 2.5

Why is it important that warfarin also inhibits natural anticoagulants protein c and protein S

Can occur within hours (unlike clotting factors which can take days) and cause hyper-coagulable state

How is warfarin metabolised

Cytochrome P450

How to reverse warfarin

2-10mg IV Vit K


Octaplex replenish factors 2/7/9/10 (25-50 units/kg)

How does heparin work

Potentiates anti-thrombin


Inactivatea thrombin and Xa

How is LMW heparin administered

SC injection

How to administer Unfractionated heparin

IV infusion

When are we most likely to use unfractionated heparin

Patients with renal failure

What creatinine clearance must be reached to use LMW heparin

30ml/min

Names of LMW heparin

Tinzaparin 175U/kg


Enoxaparin 1.5mg/kg

Rivaroxaban what does it inhibit

Xa

What does dibigatran inhibit

Thrombin

Dosing dibigatran

110mg bd

Doing for rivaroxaban

15mg bd

Action of aspirin

Cycloxygenase inhibitor

Clopidigrel action

ADP receptor blocker

Fibrinolytic agents

Alteplase /TPA (tissue plasminogen activator)/ streptokinase