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6 Cards in this Set

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methotrexate

Antimetabolite



Cell cycle specific


blocks dihydrofolateReductase (DHFR)

etoposide

DNA topological


Cell cycle specific


prevents DNA coiling

vincristine

Mitotic-blocking alkaloid (blocks MT polymerization in M phase)


Cell cycle specific

doxorubicin

Intercalating antibiotic


Cell cycle non-specific


binds to DNA, blocks replication and transcription

cyclophosphamide

Alkylating agent (mustard gas)


Cell cyclenon-specific


damages (alkylates) DNA... triggers cell death



tamoxifen

Hormonal antagonist


Cell cyclenon-specific


analogue of estrogen


reduces promotion of cell division