Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Name the carbapenem agents
|
Imipenem
Meropenem Doripenem Ertapenem |
|
|
What do carbapenem agents cover well?
|
MSSA
Streptococcus ESBL-GNRs Pseudomonas (Not ertapenem) Acinetobacter (Not ertapenem) |
|
|
What are the adverse effects of carbapenems?
|
Similar to other Beta-lactams, but with a higher incidence of seizures (especially imipenem) - renal dosing is important to prevent this!
|
|
|
Why is cilastatin coadministered with imipenem?
|
Imipenem is metabolized to a nephrotoxic metabolite in the kidney
Cilastatin inhibits the renal dehydropeptidase that causes this metabolism |
|
|
Carbapenems are some of the broadest antibiotics that exist (especially imipenem, doripenem, and meropenem)
|
They are a bad empiric choice for community acquired infections
They are a good choice for nosocomial acquired infections |
|
|
What is the significance of ertapenem having more deficient activity?
|
This makes it a poor choice for empiric therapy, especially in nosocomial pneumonia, in which psueudomonas and acinetobacter are prevalent organisms
|
|
|
Why is ertapenem a better choice for susceptible pathogens in the home infusion setting?
|
It is administered once daily where the other agents are dosed multiple times
|
|
|
Cross allergenicity with PCN allergies exists
|
But it is very low (still take it seriously however)
|
|
|
All carbapenems are good for these infections
|
Mixed aerobic/anaerobic infections
Infections caused by ESBL organisms Intra-abdominal infections |
|
|
Imipenem, Doripenem, and Meropenem are good for these infections
|
Nosocomial pneunomia
Other nosocomial infections Febrile neutropenia |
