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15 Cards in this Set
- Front
- Back
Carbapenem members and general spectrum
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Imipenem, meropenem, doripenem, ertapenem
Broadest antibacterial spectrum of the B-lactam class |
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Are carbapenems B-lactamase stable?
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Yes; however cases of resistance (carbapenemases) have occurred
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Imi/mero/doripenem spectrum specific coverage (4)
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S. aureus (MSSA)
Enterobacteriaceae (including ESBLs) SPACE organisms Anaerobes |
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Ertapenem spectrum specific coverage
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Same except no activity against pseudomonas or acinetobacter
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Clinical use of imi/mero/doripenem
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Empiric therapy for polymicrobial, nosocomial, and suspected MDR infections
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Does imipenem resistance predict mero/dori resistance?
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Nope
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What carbapenem is approved for meningitis?
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Meropenem
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What serious infections does ertapenem not cover?
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Pseudomonas and acinetobacter
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What is special about ertapenem's half life?
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It's long and therefore allows for once daily dosing
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Monobactam and route
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Aztreonam
IV 1-2 g q6-8h |
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Aztreonam coverage
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Gram negative activity only
Enterobacteriaceae Some pseudomonas activity |
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What pathogens is Aztreonam intrinsically resistant to?
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Burkholdera, Stenotrophomonas, and Acinetobacter spp.
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Can Aztreonam be used in patients ith hypersensitivity to other B-lactams?
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Yes
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Is Aztreonam recommended for usage in combination with gram positive agents?
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Aztreonam is effective when used in combination with gram positive agents
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What happens when carbapenems are used with Gancyclovir or valproic acid?
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Increased risk of seizures
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