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26 Cards in this Set
- Front
- Back
Sulfa Drugs |
Block synthesis of folic acid, thus nucleic acids |
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Isonazid |
Nictoamide analog Only effects mycobacterium Effects mycologic synthesis (part of cell wall) TB |
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Quinolones |
interferes with DNA Gyrase Prevents supercoiling Floroquinolones- have added floro group Treat UTI's agricultural use |
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Ciproflaxin |
(Quinolone) Anthrax |
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Moxiflavocan |
(Quinolone) TB |
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Nucleic acid analogs |
Prevent Replication, Transcription, Translation |
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Acyclovir, Ganoclovir |
(Nucleic acid analog) Herpes |
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B-Lactam |
Cell wall inhibitor Binds to inactive transpeptidase Prevents cross bridge formation |
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Penicillin |
(B-Lactam) Natural types G and V |
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Ampicillin |
Resistant to B-Lactamases |
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Methocillin |
(Penicillin) MRSA is Resistant |
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Augmentin |
Amoxicillin + Clavolanic acid |
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Cephalosporins |
B-lactam ring and Dihydrodiol ring More resistant to B-lactamase 4 Generations 1. Just G+ 2. G- 3. Peseudomonas 4. Oral |
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Ceftriaxone |
(Cephalosporin) gonorrhea |
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Carbapenems |
Synthetic B-Lactam |
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Doripenem |
(Carbapenem) Pseudomonas Aerogonia |
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Bacatracin |
(Cell Wall inhibitor) Topical Antibiotic Streptococcus, and Staphylococcus |
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Vanocymicin |
(Cell Wall inhibitor) Glycopeptide from amalcytase |
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Aminoglycosides |
amino sugars with glycidic linkages Kanamyosin, Centramycin, neomycin Change shape of 30S subunit cause mRNA misreading Harmful to Host |
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Macrolides |
Large lactose rings connected to sugars Binds to 50S subunit, prevents movement of mRNA Erythromycin, Z-Pak, |
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Tetracyclines |
4 rings, lots of modification possible From Streptomyces Interfere with tRNA attachment |
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Chloramphnicol |
Binds to 50S subunit inhibits peptide bond formation Supressed bone marrow formation |
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Oxazolidinones |
Synthetic Binds to 50S prevents 30S from attaching Effective against MRSA |
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Daptomycin |
(Plasma Membrane Injury) Puts pores in membrane, lyses cell |
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Polymyxin b lipopeptide |
(Plasma Membrane Injury) Pseudomonas With Bacatracin makes neosporin |
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platensimycin |
Fatty Acid Inhibition MRSA New Class of Drug Unique mode of action |