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22 Cards in this Set
- Front
- Back
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Cephalosporin |
…. |
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First gen |
iv: cefazolin-cephalothin-cephapirin OP: cefadroxil-cephalexin iv-op: cephradine |
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Second gen |
iv: cefotetan-cefmetazole-cefoxitin OP:Cefprozil iv-op: cefuroxime |
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Third gen |
iv: ceftriaxone-cefotaxime OP:cefdinir-cefixime |
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Third gen & fourth gen |
iv: ceftriaxone-cefotaxime OP:cefdinir-cefixime Cefepime |
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Cefadroxil |
Kinetic: 6 well ab OP - no food inter ab - pb is 28.1% - 90% uncha in urin within 24 h - detect in placent breast - T1/2 1.5 h |
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cefuroxime |
use: otitis media - gonorrhoea |
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ceftriaxone |
MOA: inhibit mucopeptide by carboxypeptidase- endo -trans Kinetic: 7 Inj: iv iM - bio 1% OP - vd 5.78-13.5 L - good CSF use meni - pb 95% -primar eli urin 33-67% remainder eli bile |
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Penicillin |
……….. |
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Penicillin |
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Anti pseudomonal 🤦🏻♂️🤦🏻♂️🤦🏻♂️ |
All are inj focus |
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Penicillin V |
Kinetic: 7 Vd: 35.4 - small amount in various tissue & high in kidney lesser in skin liver intestine - found in CSF -detecte in place breast - pb 50-80 - rapidly excr in urin only 25% of dose detected in urin - renal excre decr in neo infant patie renal im |
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Nafcillin |
Kinetic: 4 500mg iv =>pc= 30qg/ml aft 5m - widely distributed in vari body fl - hepatic M aco les 30% of biotra - primary eli by non renal route namely hepatic inac and excr in bile |
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Flucloxacillin |
Bio 50-70 |
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Broad spectrum |
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Amoxi & ampi |
Amoxi treat +++ Ampi treat + - and anaerobic |
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Anti pseudo monal |
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Azlocillin |
Kinetic: 3 No absorption eli by renal Biotrans within body tissue & intraintest degradation by bowel bacteria with high c in bil |
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Piperacillin |
Kinetic: 5 No absorption Vd: 101mL/kg eli primarily by glomer filtrat and tubular secretion excre rapidly as unchange in high c in urin excr by biliary as well , can use in restricted kidney function |
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Aminoglycoside |
No absorption => iv im soluble in alkaline ph concentration in renal cortex |
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Gentamycin |
Treat aerobic infecti عكس ampi excr primary by kidney in normal kidney function => 70% of initial dose recovered in urin within 24h |
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Amikacin |
Treat joint - intra abdominal inf Treat multidrug-resistant TB inj => iv im MOA: bind to 30s ribosomal |
