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73 Cards in this Set
- Front
- Back
antiarrythmic acts same mechanism as ?
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local anestethics
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Class 1 drugs slows phase
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rising of phase 0
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Class 1 causes
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decreased excitability and contraction
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Class 1 drugs are
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use -dependance
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Class 1a
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prolongs the ap and slows phase 0
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Class 1b
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shortens the refractory period
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Class 1c
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slows rise phase 0
slowing of conductance |
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three class 1a drugs
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Quinidine Procainamide Disopyramide
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procainamide is adjusten in wich patients
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renal failure patients
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Quinidine can induce
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polymorphic ventricular tachycardia
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toxic levels of quinidine ?
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Nausea Vomiting Diarrhea
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Quinidine treats
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atrial , AV-junction and ventricular tachycardia
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Procainamide actions
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are similar to quinidine
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Procainamide adverse
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CNS depression hallucinatory
induces hypotension |
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Disppyramide causes
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peripheral vasocontriction
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Disopyramide used in
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ventricular arrythmias
also has class 3 activity |
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quinidine also has class what activity
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class 3
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Quinidine stops
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Na channels and also K during refractory
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Class 2 drugs ?
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Lidocaine
Mexiletine |
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Lidocaine shortens
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phase 3 of the AP
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Lidocaine decreases
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duration of the AP
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Emergency antiarrythmic agent
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Lidocaine
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Lidocaine rapidly
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associates and dissociates from Na+ channels
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Lidocaine useful in treating
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ventricular arrhythmia during myocardial ischemia
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Lidocaine has little effect on
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atrial and AV-junction arrythmias
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Tocainide is a class ?
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class 1c antiarrythmic
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what to use in chronic ventricular arrhythmia
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Mexiletine
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Tocainide to treat
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Ventricular tachyarrhythmia
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Class 1c drugs
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Flecainide
Propafenone |
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Flecainide approved for ?
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refractory ventricular arrhytmia
also premature contraction paroxysmal supraventricular tachycardia |
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action of flecainide
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suppreses phase 0 upstroke in purkinje and myocardial fibers
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how is flecainide decreasing automacity
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by rising the threshold
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Wich drug has a negative inotropic effect
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Flecainide
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Whats slows conduction in all cardiac tissues
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Propafenone
its a broad spectrum |
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Flecainide atrial or ventricular
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mostly ventricular
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which class is b-adrenergic blockers
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Class 2 antiarrythmics
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Class 2 drugs diminishes
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phase 4 depolarisation
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Class 2 effect is
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slows heart rate and decreases contractility
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what is useful in sympathetic induced tachyarrhythmia
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class 2 anti A
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most widely used B-blocker in cardiac arrythmias
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metoprolol
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Metoprolol reduces risk of
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bronchospasm
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Propranolol reduces
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arrhythmic death after MYI
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Propranolol prevents
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ventricular arrhythmia
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Esmolol is a
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short acting B-blocker
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Esmolol used in
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acute arrhythmias
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Class 3 drugs acts by
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blocking potassium channels
prolongs AP, not Phase0 |
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Mention four class3 drugs
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Amiodarone Dronedarone Sotalol
Dofetilide |
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Amiodarone contains
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iodine
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Amiodarone dominant effect is
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prolonged AP
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Amiodarone also has
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antianginal effect swell aniarrhthymic
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Amiodarone to treat
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severe refractory supraventri
ventricular tachyarrhythmia atrial fibrillation |
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Most commonly employed antiarrhythmic
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Amiodarone
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Amiodarone side effects
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pulmonary fibrosis
Gi tract and liver toxicity blueskin due to iodine |
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Dronedarone has less what?
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tissue accumulation
do not have the iodine |
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Dronedarone side effects
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Gastrointestinal nausea vomiting
diarrhea |
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Which is most effective and most safest Amiodarone Dronedarone
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Amiodarone more effectine Dronedarone is more safe
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Sotalol has a
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non selective B-blocker activity
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I-sotalol use in
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B-blocker use
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d-sotalol use in
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anti arrhythmic use
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Sotalol blocks
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rapid K+ outward current
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what can be used in patient with persistent atrial fibrillation
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Dofetilide
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Dofetilide is for ?
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atrial fibrillation
is recommended by experts |
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Class 4 anti arrhythmic are
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calcium channel blockers
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Class 4 decreases
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phase 4 spontaneous depol
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Class 4 slows
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AV node
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Class 4 major action on
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vascular smooth muscle and heart
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which class 4 is more on the heart
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Verapamil
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which class 4 drug acts more on vascular smooth muscle
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nifepidine
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Class 4 drugs are
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Verapamil Nifedipine Diltiazem
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which class 4 are use dependent
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Verapamil Diltiazem
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Verapamil and Diltiazem only responds to
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open depolarized channels
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Class 4 more on
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atrial arrhythmias
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are associated with Torsades ?
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Quinidine, disopyramide, and procainamide
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