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13 Cards in this Set
- Front
- Back
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Anti Virals |
Major modes of action: Block penetration of virus into hos cells Block transcription & translation of viral molecules Prevent maturation of viral particles |
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Amantadine |
Inhibits influenza A virus replication |
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Acyclovir |
Disrupts Herpesvirus replication
Inactivates DNA polymerase |
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Ribavirin |
Blocks RNA synthesis It can treat severe lung infections caused by respiratory syncytial virus (RSV) when inhaled. In its oral form it can be used with an interferon medicine to treat hepatitis C. |
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Interferon (IFN) |
Produced synthetically
Decreases time of healing & complications in certain infections
Decreases cold & papillomavirus symptoms
Treats hepatitis C & genitalwars in AIDS patients
Has potential serious side effects |
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Modes of action |
Inhibition of virus entry Inhibition of Nucleic Acid synthesis Inhibition of Viral Assembly & Release |
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Inhibition of Virus Entry |
A drug may block HIV infection by preventing the binding of viral GP-41 receptors to cell receptor one, therby preventing fusion of the virus with the cell
Example: Enfuvirtide (Fuzeon)
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Inhibition of Virus Entry and release |
A drug may block entry of influenza virus by interfering with fusion of virus with cell membrane also interferes with release from membrane inhibits the action of influenza neuraminidase required for entry of virus into cell and inhibits Viral assembly. Examples: Amantadine, Zanamivir (Relenza), Oseltamivir (Tamiflu) |
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Inhibition of Nucleic Acid Synthesis |
Drugs (Purine analogs) that terminate DNA replication in herpesviruses Examples: Acyclovir (Zovirax), Vidarabine |
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Inhibition of Nucleic Acid Synthesis (ribavirin) |
Purine analog, used for respiratory syncytial virus (RSV) and some hemorrhagic fever viruses Example: Ribavirin |
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Inhibition of Nucleic Acid Synthesis |
Nucleotide analog reverse transcriptase (RT) inhibitors; stop action of RT in HIV blocking viral DNA production Examples: Zidovudine (AZT), lamivudine (3T3), Didanosine (DDI), Zalcitabine (ddC), and Stavudine (d4T) |
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Inhibition of Nucleic Acid Synthesis |
Nonnucleotide analog reverse transcriptase inhibitors; attach to HIV RT binding site, stopping its action Examples: Nevirapine, Efavirenz, Delavirdine |
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Inhibition of Viral Assembly and Release |
Protease inhibitors; insert into HIV protease, stopping its action and resulting in inactive nonifectious viruses Examples: Indinavir, saquinavir |
