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35 Cards in this Set
- Front
- Back
What are the positive effects of anti-psychotics?
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Diminish positive symptoms: hallunciations, delusions, thought disorder.
Slightly diminish negative symptoms: blunted affect, lack of motivation, cognitive impairment. |
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How do anti-psychotics basically work?
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Antagonise dopamine receptors, resulting in anti-psychotic effects.
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What are the indications for use of antipsychotics?
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Schizophrenia
Acute mania Psychotic depression Conventional Atypical |
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Name 5 conventional (typical) anti-psychotic drugs.
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Would the DOLL like a MAGAZINE and to fix all (THIXOL?)
Haloperidol. Chlorpromazine. Flupenhazine. Flupenthixol. Zuclopenthixol. |
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Name 6 atypical antipsychotic drugs.
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I take PRIDE in having DONE a PINE tree to safe my SOUL (zole).
Amisulpride Respiridone Olanzapine Clozapine Quetiapine Ariprazole |
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Which has a greater effect on EPSE? Atypicals or typicals.
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Atypicals have a lower incidence of EPSE compared to typicals.
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Aside from dopamine receptors, which other neuroreceptors can antipsychotics effect?
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Acetylcholine, histamine and serotonin receptors.
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Which two atypical antipsychotic drugs are most likely to cause weight gain?
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Clozapine.
Olanzapine. |
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Which three atypical antipsychotic drugs are most likely to cause increased serum lipids and impaired glucose tolerance?
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Clozapine.
Olanzapine. Quetiapine. |
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What are the anticholinergic side-effects?
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Dry mouth, blurred vision, constipation, urinary hesitancy.
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What are the physical manifestations of the side-effect of hyperprolactinaemia?
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Galactorrhoea
Amenorrhoea Decreased libido Sexual dysfunction |
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What cardiac side-effect can be caused by anti-psychotic drugs?
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QTc prolongation.
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What is neuroleptic malignant syndrome?
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A potentially fatal side-effect of antipsychotic drugs. There are high-temperatures, muscled rigidity, altered conciousness, raised creatinine kinase.
Need to cease medication. It can happen any time during treatment. |
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What are the positive effects of anti-psychotics?
|
Diminish positive symptoms: hallunciations, delusions, thought disorder.
Slightly diminish negative symptoms: blunted affect, lack of motivation, cognitive impairment. |
|
How do anti-psychotics basically work?
|
Antagonise dopamine receptors, resulting in anti-psychotic effects.
|
|
What are the indications for use of antipsychotics?
|
Schizophrenia
Acute mania Psychotic depression Conventional Atypical |
|
Name 5 conventional (typical) anti-psychotic drugs.
|
Would the DOLL like a MAGAZINE and to fix all (THIXOL?)
Haloperidol. Chlorpromazine. Flupenhazine. Flupenthixol. Zuclopenthixol. |
|
Name 6 atypical antipsychotic drugs.
|
I take PRIDE in having DONE a PINE tree to safe my SOUL (zole).
Amisulpride Respiridone Olanzapine Clozapine Quetiapine Ariprazole |
|
Which has a greater effect on EPSE? Atypicals or typicals.
|
Atypicals have a lower incidence of EPSE compared to typicals.
|
|
Aside from dopamine receptors, which other neuroreceptors can antipsychotics effect?
|
Acetylcholine, histamine and serotonin receptors.
|
|
Which two atypical antipsychotic drugs are most likely to cause weight gain?
|
Clozapine.
Olanzapine. |
|
Which three atypical antipsychotic drugs are most likely to cause increased serum lipids and impaired glucose tolerance?
|
Clozapine.
Olanzapine. Quetiapine. |
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Which typical drugs can be used as depot antipsychotics?
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Zuclopenthixol, Flupenthixol, Flupenhazine.
Zuclopenthixol - good for agitated, disturbed, aggressive behaviour. Flupenthixol - may have mood elevating effects. Flupenhazine - EPSE common. |
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Which atypical drugs can be used as depot antipsychotics?
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Risperidone - called Risperdal Consta.
Onset of action is 3 weeks, therefore need oral respiridone to supplement until peak plasma is reached. |
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Which drugs are most likely to cause hyper-prolactinaemia?
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Risperidone, paliperidone.
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Which drug never causes hyper-prolactinaemia?
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Asenapine.
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Which drugs are most likely to cause weight gain?
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Olanzapine, clozapine, chlorpromazine.
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Which drugs never cause weight gain?
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Ziprasidone, asenapine, sertindole.
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Which drugs are most likely to cause postural hypotension?
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Clozapine, chlorpromazine, risperidone depot.
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Which drugs have no anticholinergic side-effects?
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Amisulpride.
Amiprazole. Risperidone. Paliperidone. |
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What are the acute EPSE?
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Akithesia
Dystonia Tremor Parkinsonism (shuffling gait, reduced arm swing, mask-like facial features, retropulsion, tremor, cog-wheel rigidity) Tremor |
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What are the tardive EPSE?
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Tardive dyskinesia: involuntary hyperkinetic movements such as lip-smacking, jaw-writing, chewing, tick-like movments.
Tardive akithisa. Tardive dystonia. |
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What is the management of acute EPSE?
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Reduce dose or change medication if possible.
Can give anticholinergic medication: benztropine 1-2 mg orally, benzhexol 2 - 5mg orally? |
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How is akithisia best managed?
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Beta-blockers, e.g. propanolol.
Benzodiazepines, e.g. diazepam. |
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How do you manage tardive EPS?
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Benzodiazepines can provide some relief.
Changing to an atypical, e.g. clozapine, can help. May resolve spontaneously. |