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4 Cards in this Set
- Front
- Back
Asparin |
irreversible blocks COX enzyme TxA2 cannot be made, platelets activation decreased Alters balance between TxA2 and prostacyclin |
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Why are only low does of asparin given? |
Avoid reducing COX enzyme in epithelium too much Too much would prevent Prostacyclin being producing |
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Drugs that act on Platelet glycoproteins |
Ticagrelor Has action on platelet glycoproteins Allosterically inhibits ADP receptor, a receptor responsible for platelet activation Used during heart attacks Clopidogrel Binds irreversibly to ADP receptor Used during stroke |
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Drugs that raise cAMP levels |
Raising cAMP levels within platelets prevents aggregation Prostacylin analogue drug (Epoprostenol) Adds to normal PGI2 >> IP3 system limited use, as it has short half-life Given IV, not orally |