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4 Cards in this Set

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Asparin

irreversible blocks COX enzyme


TxA2 cannot be made, platelets activation decreased 


Alters balance between TxA2 and prostacyclin

irreversible blocks COX enzyme




TxA2 cannot be made, platelets activation decreased




Alters balance between TxA2 and prostacyclin

Why are only low does of asparin given?

Avoid reducing COX enzyme in epithelium too much


Too much would prevent Prostacyclin being producing

Avoid reducing COX enzyme in epithelium too much




Too much would prevent Prostacyclin being producing

Drugs that act on Platelet glycoproteins


Ticagrelor




Has action on platelet glycoproteins




Allosterically inhibits ADP receptor, a receptor responsible for platelet activation




Used during heart attacks




Clopidogrel




Binds irreversibly to ADP receptor




Used during stroke

Drugs that raise cAMP levels

Raising cAMP levels within platelets prevents aggregation




Prostacylin analogue drug (Epoprostenol)




Adds to normal PGI2 >> IP3 system




limited use, as it has short half-life




Given IV, not orally