Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/17

Click to flip

17 Cards in this Set

  • Front
  • Back

Structures inhibited



Peptidoglycan


-transpeptidase


-dna gyrase


-ribosome


-rna polymerase


-

Peptidoglycan Synthesis Antibiotics

Beta lactam


-Glycopeptides







Beta Lactam

Penicillin


cephalosporin


monobactem


carbapenem




inhibit tranpeptidase


bactericidal

Glycopeptides

Cover last 2 aminoacids


disrupts transpeptidase indirectly


-Bactericidal


-Does't affect gram -ve

Bacterial Ribosomes Antibiotics

Small Subunit : -aminoglycosidides (gentamicin,Streptomicin)


-Tetracyclins




Large subunit:- Macrolides (erythromicin)


-chloromphenicol

Nucleotide Biosynthesis

Sulfonamide


Trimethoprim

nucleic acid synthesis Anti biotics

Dna Gyrase: - nalidixic acid | quinolone, fluoroquinolone




Rna Polymerase : - rifampin rifampicin

cell membrane Antibiotics

Make Pores in membrane


- not selective in toxicity


- ointments administration


-Polymyxin

Drug resistance



-Natural resistance due to cell wall issues


-Acquired Resistance : *mutations + Gene Transfer

Mutation-based acquired resistance

-Porin, Transporter mutations


-Binding site mutation



Horizontal Gene transfer (Transduction, Transformation, Conjugation)

-Efflux Pumps


-inactivation of AB due to chemical bond formation or breaking


-chemically modifying AB binding site

other reasons for resistance

-Osmotic Pressure


-Foreign bodies that prevent attachment


-Abcess


-Biofilms


-calculi

Anti fungal

-amphotericin B


-azoles


-caspofungin

VIRUSES | anti-influenzae

Amantidine


Tamiflu

Anti-Herpes

acyloclovir


foscarnet

Broadspectrum

Cidofovir (papovirus, Herpes, adenoirus, poxvirus)

Anti HIV

Reverse transcriptase inh.


Integrase inh.


protease inh.


fusion inh.




Cocktail drug is used